Mutations of BRAF and BIRC3 Identify a Subgroup of Chronic Lymphocytic Leukemia with Very Poor Prognosis upon FCR Treatment

被引：0

作者：

Moia, Riccardo ^{[1
]}

Diop, Fary ^{[1
]}

Favini, Chiara ^{[1
]}

Spaccarotella, Elisa ^{[1
]}

De Paoli, Lorenzo ^{[1
]}

Bruscaggin, Alessio ^{[2
]}

Spina, Valeria ^{[2
]}

Cerri, Michaela

Deambrogi, Clara ^{[1
]}

Kodipad, Ahad Ahmed ^{[1
]}

Favini, Simone ^{[1
]}

Sagiraju, Sruthi ^{[1
]}

Jabangwe, Clive ^{[1
]}

Mauro, Francesca Romana ^{[3
]}

Del Giudice, Ilaria ^{[3
]}

Forconi, Francesco ^{[4
,5
,6
]}

Cortelezzi, Agostino ^{[7
,8
]}

Zaja, Francesco ^{[9
]}

Visco, Carlo ^{[10
]}

Chiarenza, Annalisa ^{[11
]}

Rigolin, Gian Matteo ^{[12
]}

Marasca, Roberto ^{[13
]}

Coscia, Marta ^{[14
,15
]}

Perbellini, Omar ^{[16
]}

Tedeschi, Alessandra ^{[17
]}

Laurenti, Luca ^{[18
]}

Motta, Marina ^{[19
]}

Del Poeta, Giovanni ^{[20
]}

Cuneo, Antonio ^{[12
]}

Gattei, Valter ^{[21
]}

Foa, Robin ^{[3
]}

Gaidano, Gianluca ^{[1
]}

Rossi, Davide ^{[2
]}

机构：

[1] Amedeo Avogadro Univ Eastern Piedmont, Dept Translat Med, Div Hematol, Novara, Italy

[2] Inst Southern Switzerland, Inst Oncol Res & Oncol, Bellinzona, Switzerland

[3] Sapienza Univ, Dept Cellular Biotechnol & Hematol, Hematol, Rome, Italy

[4] Univ Southampton, Southampton Canc Res UK, Canc Sci Unit, Southampton, Hants, England

[5] Univ Southampton, Natl Inst Hlth Res, Expt Canc Med Ctr, Southampton, Hants, England

[6] Univ Siena, Div Hematol, Siena, Italy

[7] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Dept Hematol Oncol, Milan, Italy

[8] Univ Milan, Milan, Italy

[9] Univ Udine, DAME, Clin Ematol, Udine, Italy

[10] Osped San Bortolo, Dept Cell Therapy & Hematol, Vicenza, Italy

[11] Azienda Osped Univ Policlin OVE, Div Hematol, Catania, Italy

[12] Univ Ferrara, Azienda Osped Univ Arcispedale S Anna, Hematol Sect, Ferrara, Italy

[13] Univ Modena & Reggio Emilia, Dept Hematol & Oncol, Div Hematol, Modena, Italy

[14] Azienda Ospedaliero Univ Citta Salute & Sci, Div Hematol, Turin, Italy

[15] Univ Turin, Turin, Italy

[16] Univ Verona, Dept Med, Sect Hematol, Verona, Italy

[17] Osped Niguarda Ca Granda, Niguarda Canc Ctr, Dept Oncol Haematol, Milan, Italy

[18] Univ Cattolica Sacro Cuore, Inst Hematol, Rome, Italy

[19] Spedali Civil Brescia, Dept Hematol, Brescia, Italy

[20] Tor Vergata Univ, Dept Hematol, Rome, Italy

[21] IRCCS, Ctr Riferimento Oncol, Clin & Expt Oncohematol Unit, Aviano, Italy

来源：

CLINICAL LYMPHOMA MYELOMA & LEUKEMIA | 2017年 / 17卷 / 10期

关键词：

chronic lymphocytic leukemia; FCR; immunochemotherapy; molecular predictors; precision medicine;

D O I：

10.1016/j.clml.2017.09.039

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

CLL-009

引用

页码：S11 / S12

页数：2

共 50 条

[21] Clinical impact of clonal and subclonal TP53, SF3B1, BIRC3, NOTCH1, and ATM mutations in chronic lymphocytic leukemia
Nadeu, Ferran
Delgado, Julio
Royo, Cristina
Baumann, Tycho
Stankovic, Tatjana
Pinyol, Magda
Jares, Pedro
Navarro, Alba
Martin-Garcia, David
Bea, Silvia
Salaverria, Itziar
Oldreive, Ceri
Aymerich, Marta
Suarez-Cisneros, Helena
Rozman, Maria
Villamor, Neus
Colomer, Dolors
Lopez-Guillermo, Armando
Gonzalez, Marcos
Alcoceba, Miguel
Jose Terol, Maria
Colado, Enrique
Puente, Xose S.
Lopez-Otin, Carlos
Enjuanes, Anna
Campo, Elias
BLOOD, 2016, 127 (17) : 2122 - 2130
[22] Perspectives on Precision Medicine in Chronic Lymphocytic Leukemia: Targeting Recurrent Mutations-NOTCH1, SF3B1, MYD88, BIRC3
Putowski, Maciej
Giannopoulos, Krzysztof
JOURNAL OF CLINICAL MEDICINE, 2021, 10 (16)
[23] Somatic MED12 mutations are associated with poor prognosis markers in chronic lymphocytic leukemia
Kampjarvi, Kati
Jaervinen, Tiina M.
Heikkinen, Tuomas
Ruppert, Amy S.
Senter, Leigha
Hoag, Kevin W.
Dufva, Olli
Kontro, Mika
Rassenti, Laura
Hertlein, Erin
Kipps, Thomas J.
Porkka, Kimmo
Byrd, John C.
de la Chapelle, Albert
Vahteristo, Pia
ONCOTARGET, 2015, 6 (03) : 1884 - 1888
[24] COPY NUMBER ANALYSIS OF THE BIRC3 GENE BY DROPLET DIGITAL PCR IN CHRONIC LYMPHOCYTIC LEUKEMIA PATIENTS WITH 11Q DELETION
Raponi, S.
Del Giudice, I.
Ilari, C.
Cafforio, L.
Piciocchi, A.
Marinelli, M.
Messina, M.
Mauro, F. R.
Rigolin, G. M.
Rossi, F.
Dal Bo, M.
Cuneo, A.
Gaidano, G.
Gattei, V.
Guarini, A.
Foa, R.
HAEMATOLOGICA, 2016, 101 : 223 - 224
[25] NOTCH1, SF3B1, BIRC3 and TP53 mutations in patients with chronic lymphocytic leukemia undergoing first-line treatment: correlation with biological parameters and response to treatment
Chiaretti, Sabina
Marinelli, Marilisa
Del Giudice, Ilaria
Bonina, Silvia
Piciocchi, Alfonso
Messina, Monica
Vignetti, Marco
Rossi, Davide
Di Maio, Valeria
Mauro, Francesca Romana
Guarini, Anna
Gaidano, Gianluca
Foa, Robin
LEUKEMIA & LYMPHOMA, 2014, 55 (12) : 2785 - 2792
[26] Low T3 syndrome as a predictor of poor prognosis in chronic lymphocytic leukemia
Gao, Rui
Chen, Rui-Ze
Xia, Yi
Liang, Jin-Hua
Wang, Li
Zhu, Hua-Yuan
Wu, Jia-Zhu
Fan, Lei
Li, Jian-Yong
Yang, Tao
Xu, Wei
INTERNATIONAL JOURNAL OF CANCER, 2018, 143 (03) : 466 - 477
[27] Postremissional rituximab administration for the treatment of poor prognosis chronic lymphocytic leukemia (CLL) patients.
Mauro, FR
Gentile, M
Alimena, G
De Propris, S
Cimino, G
Giammartini, E
Buffolino, S
Mandelli, F
Foa, R
BLOOD, 2002, 100 (11) : 361B - 361B
[28] Variant t(9;22) translocation may identify a subgroup of chronic myeloid leukemia patients with poor prognosis.
Albano, F
Specchia, G
Pannunzio, A
Roberti, MG
Buquicchio, C
Mestice, A
Greco, G
Liso, V
BLOOD, 2001, 98 (11) : 321A - 321A
[29] Frequencies of SF3B1, NOTCH1, MYD88, BIRC3 and IGHV mutations and TP53 disruptions in Chinese with chronic lymphocytic leukemia: disparities with Europeans
Xia, Yi
Fan, Lei
Wang, Li
Gale, Robert Peter
Wang, Man
Tian, Tian
Wu, Wei
Yu, Liang
Chen, Yao-Yu
Xu, Wei
Li, Jian-Yong
ONCOTARGET, 2015, 6 (07) : 5426 - 5434
[30] HIGH RISK CYTOGENETICS, ELEVATED LDH AND ISS-3 IDENTIFY A SUBGROUP OF MYELOMA PATIENTS WITH VERY POOR PROGNOSIS
Kastritis, E.
Terpos, E.
Roussou, M.
Gavriatopoulou, M.
Iakovaki, M.
Kalapanida, D.
Kanellias, N.
Eleutherakis-Papaiakovou, E.
Gika, D.
Dimopoulos, M.
HAEMATOLOGICA, 2013, 98 : 334 - 334

← 1 2 3 4 5 →