Identification and quantitation of sodium-thyroxine and its degradation products by LC using electrochemical and MS detection

被引：30

作者：

Kazemifard, AG ^{[1
]}

Moore, DE

Aghazadeh, A

机构：

[1] Univ Tehran Med Sci, Coll Pharm, Tehran, Iran

[2] Univ Sydney, Dept Pharm, Sydney, NSW 2006, Australia

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2001年 / 25卷 / 5-6期

关键词：

sodium-thyroxine; degradation products; high-performance liquid chromatography; amperometric detection; HPLC-mass spectrometry;

D O I：

10.1016/S0731-7085(01)00370-3

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

High performance liquid chromatography (HPLC) was used in combination with an amperometric and mass spectrometric detection to elucidate and quantitate the degradation products and contaminants of the photo-sensitive Na-thyroxine. Using HPLC with amperometric detection, seven decomposition compounds were separated. These products, which occur mostly as contaminants, were then identified by a developed liquid chromatography-mass spectrometry technique. The same HPLC method was also employed to analyze Na-thyroxine and its degradation products in three commercially available brands of Na-thyroxine tablets. (C) 2001 Elsevier Science B.V. AH rights reserved.

引用

页码：697 / 711

页数：15

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