Identification and quantitation of sodium-thyroxine and its degradation products by LC using electrochemical and MS detection

被引：30
|
作者：
Kazemifard, AG [1 ]
Moore, DE
Aghazadeh, A
机构：
[1] Univ Tehran Med Sci, Coll Pharm, Tehran, Iran
[2] Univ Sydney, Dept Pharm, Sydney, NSW 2006, Australia
来源：
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2001年 / 25卷 / 5-6期
关键词：
sodium-thyroxine; degradation products; high-performance liquid chromatography; amperometric detection; HPLC-mass spectrometry;
D O I：
10.1016/S0731-7085(01)00370-3
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
High performance liquid chromatography (HPLC) was used in combination with an amperometric and mass spectrometric detection to elucidate and quantitate the degradation products and contaminants of the photo-sensitive Na-thyroxine. Using HPLC with amperometric detection, seven decomposition compounds were separated. These products, which occur mostly as contaminants, were then identified by a developed liquid chromatography-mass spectrometry technique. The same HPLC method was also employed to analyze Na-thyroxine and its degradation products in three commercially available brands of Na-thyroxine tablets. (C) 2001 Elsevier Science B.V. AH rights reserved.
引用
收藏
页码：697 / 711
页数：15
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