Butane-2,3-diacetal-desymmetrized glycolic acid -: A new building block for the stereoselective synthesis of enantiopure α-hydroxy acids

被引：0
|
作者：
Díez, E [1 ]
Dixon, DJ [1 ]
Ley, SV [1 ]
机构：
[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2001年 / 40卷 / 15期
关键词：
alkylation; alpha-hydroxy acids; asymmetric synthesis; chiral memory; diastereoselectivity;
D O I：
10.1002/1521-3773(20010803)40:15<2906::AID-ANIE2906>3.0.CO;2-5
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
According to a chiral memory protocol, a chiral glycolic acid equivalent, the butane-2,3-diacetal-desymmetrized glycolate 2, is obtained from chiral 3-halopropane-1,2-diols 1. Compound 2 is a new and effective building block for the synthesis of mono- and dialkylated α-hydroxy acids 3, which constitute a biologically and pharmacologically important structural motif.
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收藏
页码：2906 / 2909
页数：4
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