Synthesis of acetal protected building blocks using flow chemistry with flow IR analysis: preparation of butane-2,3-diacetal tartrates

被引：61

作者：

Carter, Catherine F. ^{[1
]}

Baxendale, Ian R. ^{[1
]}

O'Brien, Matthew ^{[1
]}

Pavey, John B. J. ^{[2
]}

Ley, Steven V. ^{[1
]}

机构：

[1] Univ Cambridge, Dept Chem, Innovat Technol Ctr, Cambridge CB2 1EW, England

[2] AstraZeneca, Loughborough LE11 5RH, Leics, England

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2009年 / 7卷 / 22期

基金：

英国工程与自然科学研究理事会;

关键词：

ANNONACEOUS ACETOGENIN; MULTISTEP SYNTHESIS; ORGANIC-SYNTHESIS; NATURAL-PRODUCT; DERIVATIVES; REACTOR; UTILITY; ACID;

D O I：

10.1039/b917289k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The syntheses of butane-2,3-diacetal protected tartrate derivatives are described using continuous flow processing techniques with in-line purification and I.R. analytical protocols.

引用

页码：4594 / 4597

页数：4

共 4 条

[1] The continuous flow synthesis of butane-2,3-diacetal protected building blocks using microreactors
Carter, Catherine F.
Baxendale, Ian R.
Pavey, John B. J.
Ley, Steven V.
ORGANIC & BIOMOLECULAR CHEMISTRY, 2010, 8 (07) : 1588 - 1595
[2] Synthesis of a ceramide sphingolipid as a potential sex pheromone of the hair crab Erimacrus isenbeckii using butane-2,3-diacetal desymmetrised glycolic acid building blocks
Dixon, DJ
Ley, SV
Lohmann, S
Sheppard, TD
SYNLETT, 2005, (03) : 481 - 484
[3] Tetrabutylammonium Cyanide Catalyzed Aldol Self-Condensation of Ley's Butane-2,3-diacetal (BDA) Protected Glyceraldehydes. Synthesis of Two New BDA-Protected Sugar-Derived Scaffolds
Areces, Pilar
Carrasco, Esther
Light, Mark E.
Plumet, Joaquin
SYNLETT, 2009, (15) : 2500 - 2502
[4] New building blocks for efficient and highly diastereoselective polyol production -: Synthesis and utility of (R′,R′,S,S) and (S′,S′,R,R)-2,3-butane diacetal protected butane tetrol derivatives
Barlow, JS
Dixon, DJ
Foster, AC
Ley, SV
Reynolds, DJ
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1999, (12): : 1627 - 1629

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