Development of chitosan nanoparticles as drug delivery systems for 5-fluorouracil and leucovorin blends

被引:143
|
作者
Li, Puwang [1 ,2 ,3 ]
Wang, Yichao [1 ]
Peng, Zheng [2 ]
She, Fenghua [1 ]
Kong, Lingxue [1 ]
机构
[1] Deakin Univ, Inst Technol & Res Innovat, Ctr Mat & Fiber Innovat, Geelong, Vic 3217, Australia
[2] Chinese Acad Trop Agr Sci, Agr Prod Proc Res Inst, Zhanjiang 524001, Peoples R China
[3] Res Inst Trop Agr Machinery, Zhanjiang 524091, Peoples R China
关键词
Colon cancer; Combination chemotherapy; Drug delivery system; Chitosan nanoparticles; PH-SENSITIVE HYDROGEL; COMBINATION THERAPY;
D O I
10.1016/j.carbpol.2011.03.045
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
Both 5-fluorouracil (5-FU) and leucovorin (LV) are hydrophilic drugs which are used in combination for the treatment of colon cancer. Chitosan (CS) nanoparticles were prepared by ionic gelation technology, and then used for trapping 5-FU and LV. Combination drugs were encapsulated into CS nanoparticles as a result of electrostatic interactions, which was confirmed by Fourier transform spectroscopy (FTIR). XRD results demonstrated that the both drugs were distributed in the CS nanoparticles in the amorphous state. Efficient encapsulation efficiency (EE) and loading capacity (LC) were achieved which were correlated to their initial drug concentration. Simultaneous release of 5-FU and LV from CS nanoparticles were observed in vitro studies; both 5-FU and LV experienced initial burst release which was followed by a constant and continuous release. The release of drugs was influenced by their initial drug concentration, indicating that the release of drugs could be controlled by varying the initial drug concentration. All results suggested that CS nanoparticles are promising system for simultaneously delivering 5-FU and LV in treatment of colon cancer. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码:698 / 704
页数:7
相关论文
共 50 条
  • [11] Preparation and characterisation of 5-fluorouracil containing PLGA nanospheres coated with chitosan, for drug delivery
    Calderini, Adriana
    Pessine, Francisco B. T.
    Franchi, Gilberto C.
    Nowill, Alexandre E.
    INTERNATIONAL JOURNAL OF NANOTECHNOLOGY, 2012, 9 (10-12) : 851 - 861
  • [12] Chitosan-Coated 5-Fluorouracil Incorporated Emulsions as Transdermal Drug Delivery Matrices
    Khan, Taif Ali
    Azad, Abul Kalam
    Fuloria, Shivkanya
    Nawaz, Asif
    Subramaniyan, Vetriselvan
    Akhlaq, Muhammad
    Safdar, Muhammad
    Sathasivam, Kathiresan V.
    Sekar, Mahendran
    Porwal, Omji
    Meenakshi, Dhanalekshmi Unnikrishnan
    Malviya, Rishabha
    Miret, Mireia Mallandrich
    Mendiratta, Ajay
    Fuloria, Neeraj Kumar
    POLYMERS, 2021, 13 (19)
  • [13] Solvent effects in the development of a drug delivery system for 5-fluorouracil using magnetic mesoporous silica nanoparticles
    Egodawatte, Shani
    Dominguez, Steven, Jr.
    Larsen, Sarah C.
    MICROPOROUS AND MESOPOROUS MATERIALS, 2017, 237 : 108 - 116
  • [14] Chitosan Nanoparticles of 5-Fluorouracil for Ophthalmic Delivery: Characterization, in-Vitro and in-Vivo Study
    Nagarwal, Ramesh Chand
    Singh, Paras Nath
    Kant, Shri
    Maiti, Pralay
    Pandit, Jayanta Kumar
    CHEMICAL & PHARMACEUTICAL BULLETIN, 2011, 59 (02) : 272 - 278
  • [15] Development and characterization of hyaluronic acid decorated PLGA nanoparticles for delivery of 5-fluorouracil
    Yadav, Awesh K.
    Agarwal, Abhinav
    Rai, Gopal
    Mishra, Pradeep
    Jain, Sanyog
    Mishra, Anil K.
    Agrawal, Himanshu
    Agrawal, Govind P.
    DRUG DELIVERY, 2010, 17 (08) : 561 - 572
  • [16] Lipoic Acid Conjugated Chitosan Copolymer for the Delivery of 5-Fluorouracil
    Lee, Sun Young
    Kim, Young Jin
    POLYMER-KOREA, 2012, 36 (02) : 149 - 154
  • [17] 5-Fluorouracil, innovative drug delivery systems to enhance bioavailability for topical use
    de Oliveira, Beatriz Ewert
    Junqueira Amorim, Otavio Henrique
    Lima, Loneta Lauro
    Rezende, Rodrigo Alvarenga
    Mestnik, Natalia Cammarosano
    Bagatin, Edileia
    Leonardi, Gislaine Ricci
    JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2021, 61
  • [18] Poly(butylcyanoacrylate) nanoparticles for topical delivery of 5-fluorouracil
    Simeonova, M
    Velichkova, R
    Ivanova, G
    Enchev, V
    Abrahams, I
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2003, 263 (1-2) : 133 - 140
  • [19] Imprinted hydrophilic nanospheres as drug delivery systems for 5-fluorouracil sustained release
    Cirillo, G.
    Iemma, F.
    Puoci, F.
    Parisi, O. I.
    Curcio, M.
    Spizzirri, U. G.
    Picci, N.
    JOURNAL OF DRUG TARGETING, 2009, 17 (01) : 72 - 77
  • [20] Enhancement of 5-Fluorouracil Drug Delivery in a Graphene Oxide Containing Electrospun Chitosan/Polyvinylpyrrolidone Construct
    Grant, Jamie J.
    Pillai, Suresh C.
    Perova, Tatiana S.
    Brennan, Barry
    Hinder, Steven J.
    McAfee, Marion
    Hehir, Sarah
    Breen, Ailish
    Materials, 2024, 17 (21)