Lipoic Acid Conjugated Chitosan Copolymer for the Delivery of 5-Fluorouracil

被引：0
|
作者：
Lee, Sun Young [1 ]
Kim, Young Jin [1 ]
机构：
[1] Chungnam Natl Univ, Dept Appl Chem & Biol Engn, Taejon 305764, South Korea
来源：
POLYMER-KOREA | 2012年 / 36卷 / 02期
关键词：
chitosan; lipoic acid; 5-fluorouracil; amphiphilic polymer; drug delivery system; SELF-AGGREGATED NANOPARTICLES; DRUG-DELIVERY; SYSTEMS; CARRIER;
D O I：
10.7317/pk.2012.36.2.149
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
The amphiphilic copolymer by the conjugation of biocompatible chitosan and antioxidant lipoic acid was studied as a drug delivery carrier. The amphiphilic copolymer was self-assembled to form nanoparticles in the aqueous solution. 5-Fluorouracil widely used as an anticancer drug was encapsulated inside the nanoparticles by a solid dispersion method. The degree of branching of lipoic acid on chitosan was controlled to obtain the optimal condition for the drug delivery carrier. The sizes of nanoparticles were about 250 nm by the dynamic light scattering. The encapsulation efficiency of nanoparticles were about 10%. The copolymer with 42% degree of branching showed the best performance as a drug delivery carrier.
引用
收藏
页码：149 / 154
页数：6
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