Interactions between Innate Lymphoid Cells and Cells of the Innate and Adaptive Immune System

被引:38
|
作者
Symowski, Cornelia
Voehringer, David [1 ]
机构
[1] Univ Hosp Erlangen, Dept Infect Biol, Erlangen, Germany
来源
FRONTIERS IN IMMUNOLOGY | 2017年 / 8卷
关键词
allergic inflammation; helminths; mast cells; innate lymphoid cells; eosinophils; basophils; Th2; cells; alternatively activated macrophages; ALTERNATIVELY ACTIVATED MACROPHAGES; NATURAL HELPER-CELLS; LUNG INFLAMMATION; TYPE-2; IMMUNITY; AIRWAY INFLAMMATION; IL-33; PROMOTES; RESPONSES; EOSINOPHILS; EXPRESSION;
D O I
10.3389/fimmu.2017.01422
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Type 2 innate lymphoid cells (ILC2s) are a major source of cytokines, which are also produced by Th2 cells and several cell types of the innate immune system. Work over the past few years indicates that ILC2s play a central role in regulating type 2 immune responses against allergens and helminths. ILC2s can interact with a variety of cells types of the innate and adaptive immune system by cell-cell contacts or by communication via soluble factors. In this review, we provide an overview about recent advances in our understanding how ILC2s orchestrate type 2 immune responses with focus on direct interactions between ILC2s and other cells of the immune system.
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页数:8
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