Intestinal neuro-immune interactions: focus on macrophages, mast cells and innate lymphoid cells

被引：29
|
作者：
Stakenborg, Nathalie [1 ]
Viola, Maria F. [1 ]
Boeckxstaens, Guy E. [1 ]
机构：
[1] Univ Leuven, Dept Chron Dis Metab & Ageing, Translat Res Ctr GastroIntestinal Disorders, Intestinal Neuroimmune Interact, Leuven, Belgium
来源：
CURRENT OPINION IN NEUROBIOLOGY | 2020年 / 62卷
基金：
欧洲研究理事会;
关键词：
MECHANISM; HISTAMINE; SENSITIZATION; POTENTIATION; SEROTONIN; REVEALS; PATHWAY; TRPV1; PAIN;
D O I：
10.1016/j.conb.2019.11.020
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Intestinal homeostasis relies on the reciprocal crosstalk between enteric neurons and immune cells, which together form neuroimmune units that occupy distinct anatomical niches within the gut. Here wewill review the recent advancesin our understanding of neuro-immune crosstalk within the gut, with focus on macrophages, mast cells and innate lymphoid cells. In particular, we will discuss the role of neuron-immune cell crosstalk in homeostasis, and how aberrant communication may underlie disease in the gastro-intestinal tract.
引用
收藏
页码：68 / 75
页数：8
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