Circulating CD4+PD-1+and CD8+PD-1+T cells are profoundly decreased at the onset of fulminant type 1 diabetes and are restored by treatment, contrasting with CD4+CD25+FoxP3+regulatory T cells

被引：16

作者：

Iijima, Toshie ^{[1
]}

Kato, Kanako ^{[1
]}

Jojima, Teruo ^{[1
]}

Tomotsune, Takanori ^{[1
]}

Fukushima, Maiko ^{[2
]}

Suzuki, Kunihiro ^{[1
]}

Aso, Yoshimasa ^{[1
]}

机构：

[1] Dokkyo Med Univ, Dept Endocrinol & Metab, Shimotsuga, Tochigi 3210293, Japan

[2] LSI Medience, Tokyo, Japan

来源：

DIABETES RESEARCH AND CLINICAL PRACTICE | 2017年 / 133卷

关键词：

ANTI-PD-1; PD-1; MICE;

D O I：

10.1016/j.diabres.2017.07.036

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Programed cell death protein-1 (PD-1) is an inhibitory receptor expressed by T cells that downregulates the activation and proliferation of these cells to maintain peripheral self-tolerance. Recent studies reported some cases of new-onset type 1 diabetes (T1D) under anti-PD1 or PDL-1 antibodies. We demonstrated that circulating both CD4+PD-1+ and CD8+PD-1+ T cells were profoundly reduced at the onset of fulminant T1D and were restored by treatment in two patients with fulminant T1D. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：10 / 12

页数：3

共 50 条

[41] CD4+CD25+FoxP3+regulatory T cells enhance the allogeneic activity of endothelial-specific CD8+/CD28-CTL
Eissner, Guenther
Hartmann, Isabel
Kesikli, Altug
Holler, Ernst
Haffner, Silvia
Sax, Tanja
Schray, Carolin
Meiser, Bruno
Reichart, Bruno
INTERNATIONAL IMMUNOLOGY, 2011, 23 (08) : 485 - 492
[42] Decreased Levels of Circulating CD4+CD25+Foxp3+ Regulatory T Cells in Patients with Primary Antiphospholipid Syndrome
Ester Rosári Raphaelli Dal Ben
Carine Hartmann do Prado
Talita Siara Almeida Baptista
Moisés Evandro Bauer
Henrique Luiz Staub
Journal of Clinical Immunology, 2013, 33 : 876 - 879
[43] Type I IFN facilitates the expansion of CD4+CD25+Foxp3+regulatory T cells through upregulation of GITRL on dendritic cells
Hong, Jian
JOURNAL OF IMMUNOLOGY, 2010, 184
[44] CD4+CD25+FoxP3+ regulatory T cells in autoimmune diseases
Xavier Valencia
Peter E Lipsky
Nature Clinical Practice Rheumatology, 2007, 3 : 619 - 626
[45] Chinese medicine Ginseng and Astragalus granules ameliorate autoimmune diabetes by upregulating both CD4+FoxP3+and CD8+CD122+PD1+regulatory T cells
Wang, Yeshu
Xie, Qingfeng
Liang, Chun-Ling
Zeng, Qiaohuang
Dai, Zhenhua
ONCOTARGET, 2017, 8 (36) : 60201 - 60209
[46] Rapamycin Promotes Expansion of CD4+CD25+FOXP3+Regulatory T Cells By Modulating Fatty Acid Metabolism?
Wu, D.
Wang, L.
Cao, Y.
Xu, M.
Rong, R.
Zhu, T.
TRANSPLANTATION, 2014, 98 : 402 - 402
[47] Nitric oxide (NO) increases switching of CD4+CD25- cells into CD4+CD25+ CD127-Foxp3+ T regulatory (Tr1) cells.
Mukhopadhyay, Sangita
Qu, Xiemei
Tajpal, Neelam
Kerman, Ronald
Kahan, Barry D.
Kirken, Robert
Stepkowski, Stanislaw
AMERICAN JOURNAL OF TRANSPLANTATION, 2007, 7 : 483 - 483
[48] NAD+ alters CD4+T cell differentiation and promotes allograft survival independently of CD4+CD25+Foxp3+regulatory T cells
Elkhal, A.
Biefer, H. Rodriguez Cetina
Uehara, H.
Heinbokel, T.
Quante, M.
Krenzien, F.
Camacho, V.
Seyda, M.
Schuitenmaker, J.
de la Fuente, M. A.
Ghiran, I.
Tullius, S. G.
TRANSPLANTATION, 2016, 100 (07) : S223 - S223
[49] The role of estrogen in atrazine-mediated inhibition of CD4+T cell function and induction of CD4+CD25+Foxp3+regulatory T cells
Emmons, Tiffany
Wetzel, Scott
JOURNAL OF IMMUNOLOGY, 2014, 192
[50] CD4+CD25+FOXP3+T-regulatory cells are expanded in HTLV-1 patients with strongyloidiasis
Montes, Martin
Sanchez, Cesar
Gotuzzo, Eduardo
White, A. Clinton
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2007, 77 (05): : 282 - 282

← 1 2 3 4 5 →