CD4+CD25+FoxP3+ regulatory T cells in autoimmune diseases

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作者
Xavier Valencia
Peter E Lipsky
机构
[1] X Valencia is a physician scientist at the National Institute of Arthritis and Musculoskeletal and Skin Diseases,
[2] and PE Lipsky is the Head of the Autoimmunity Branch in the Intramural Research Program of the National Institute of Arthritis and Musculoskeletal and Skin Diseases,undefined
[3] NIH,undefined
[4] Bethesda,undefined
[5] MD,undefined
[6] USA. PE Lipsky is the Editor-in-Chief of Nature Clinical Practice Rheumatology.,undefined
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摘要
Regulatory T cells have a key role in immune homeostasis and in suppressing unwanted inflammatory responses toward self-antigens. In this Review the authors discuss the function of regulatory T cells in human autoimmune disease, focusing primarily on rheumatoid arthritis and systemic lupus erythematosus.
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页码:619 / 626
页数:7
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