Alpha-synuclein and its role in metal binding: Relevance to Parkinson's disease

被引：37
|
作者：
Wright, Josephine A. [1 ]
Brown, David R. [1 ]
机构：
[1] Univ Bath, Dept Biol & Biochem, Bath BA2 7AY, Avon, England
来源：
JOURNAL OF NEUROSCIENCE RESEARCH | 2008年 / 86卷 / 03期
关键词：
synuclein; neurodegeneration; metal; Parkinson's disease;
D O I：
10.1002/jnr.21461
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Parkinson's disease and some other neurodegenerative disorders are associated with a protein that can aggregate and form fibrils called alpha-synuclein. Like many other proteins associated with neurodegenerative disorders, this protein has no known function, and the mechanism by which it could cause diseases is poorly defined. It was recently suggested that it binds copper. This review assesses what is known about alpha-synuclein and its interaction with metals. (C) 2007 Wiley-Liss, inc.
引用
收藏
页码：496 / 503
页数：8
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