Alpha-synuclein and its role in metal binding: Relevance to Parkinson's disease

被引：37

作者：

Wright, Josephine A. ^{[1
]}

Brown, David R. ^{[1
]}

机构：

[1] Univ Bath, Dept Biol & Biochem, Bath BA2 7AY, Avon, England

来源：

JOURNAL OF NEUROSCIENCE RESEARCH | 2008年 / 86卷 / 03期

关键词：

synuclein; neurodegeneration; metal; Parkinson's disease;

D O I：

10.1002/jnr.21461

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Parkinson's disease and some other neurodegenerative disorders are associated with a protein that can aggregate and form fibrils called alpha-synuclein. Like many other proteins associated with neurodegenerative disorders, this protein has no known function, and the mechanism by which it could cause diseases is poorly defined. It was recently suggested that it binds copper. This review assesses what is known about alpha-synuclein and its interaction with metals. (C) 2007 Wiley-Liss, inc.

引用

页码：496 / 503

页数：8

共 50 条

[21] Characterising the role of alpha-synuclein in Ferroptosis in the context of Parkinson's disease
Sanchez, L. Mahoney
Devos, D.
Duce, J. A.
Ayton, S.
Devedjian, J.
EUROPEAN JOURNAL OF NEUROLOGY, 2021, 28 : 127 - 127
[22] Alpha-synuclein and Parkinson disease
Hui Liu1
NeuralRegenerationResearch, 2007, (04) : 239 - 243
[23] Role of T Cells in an Alpha-Synuclein Model of Parkinson's Disease
Subbarayan, M. S.
Hudson, C.
Litsky, N.
Nash, K.
Bickford, P. C.
CELL TRANSPLANTATION, 2019, 28 (04) : 486 - 487
[24] The role of alpha-synuclein as ferrireductase in neurodegeneration associated with Parkinson’s disease
Jeswinder Sian-Hulsmann
Peter Riederer
Journal of Neural Transmission, 2020, 127 : 749 - 754
[25] NEW EVIDENCES ON METAL BINDING TO α-SYNUCLEIN AND ITS ROLE ON OLIGOMER FORMATION: KEY RELEVANCE TO PARKINSON'S DISEASE
Cole, A. R.
JOURNAL OF NEUROCHEMISTRY, 2009, 110 : 159 - 160
[26] Investigating the Mechanisms of Antibody Binding to Alpha-Synuclein for the Treatment of Parkinson's Disease
Harrison, Malcolm C.
Lai, Pin-Kuang
MOLECULAR PHARMACEUTICS, 2024, 21 (10) : 5326 - 5334
[27] Parkinson's Disease, Cortical Dysfunction, and Alpha-Synuclein
Caviness, John N.
Lue, Lih-Fen
Beach, Thomas G.
Hentz, Joseph G.
Adler, Charles H.
Sue, Lucia
Sadeghi, Ramin
Driver-Dunckley, Erika
Evidente, Virgilio G.
Sabbagh, Marwan N.
Shill, Holly A.
Walker, Douglas G.
MOVEMENT DISORDERS, 2011, 26 (08) : 1436 - 1442
[28] Targeting Alpha-Synuclein as a Therapy for Parkinson's Disease
Fields, Carroll Rutherford
Bengoa-Vergniory, Nora
Wade-Martins, Richard
FRONTIERS IN MOLECULAR NEUROSCIENCE, 2019, 12
[29] Alpha-synuclein and the prion hypothesis in Parkinson's disease
Melki, R.
REVUE NEUROLOGIQUE, 2018, 174 (09) : 644 - 652
[30] Modeling Parkinson's Disease With the Alpha-Synuclein Protein
Gomez-Benito, Monica
Granado, Noelia
Garcia-Sanz, Patricia
Michel, Anne
Dumoulin, Mireille
Moratalla, Rosario
FRONTIERS IN PHARMACOLOGY, 2020, 11

← 1 2 3 4 5 →