Parecoxib reduces renal injury in an ischemia/reperfusion model in rats

被引：9

作者：

Calistro Neto, Jose Pedro ^{[1
]}

Torres, Romulo da Costa ^{[1
]}

Goncalves, Giovanna Maria ^{[2
]}

da Silva, Leopoldo Muniz ^{[3
]}

Custodio Domingues, Maria Aparecida ^{[4
]}

Pinheiro Modolo, Norma Sueli ^{[5
]}

Moreira de Barros, Guilherme Antonio ^{[5
]}

机构：

[1] Sao Paulo State Univ, UNESP, Botucatu Med Sch, Postgrad Program Anesthesiol, Sao Paulo, Brazil

[2] UNESP, Botucatu Med Sch, Botucatu, SP, Brazil

[3] UNESP, Botucatu Med Sch, Div Anesthesiol, Botucatu, SP, Brazil

[4] UNESP, Botucatu Med Sch, Dept Pathol, Botucatu, SP, Brazil

[5] UNESP, Botucatu Med Sch, Dept Anesthesiol, Botucatu, SP, Brazil

来源：

ACTA CIRURGICA BRASILEIRA | 2015年 / 30卷 / 04期

关键词：

Parecoxib; Ischemia; Reperfusion; Kidney; Rats; ISCHEMIA-REPERFUSION INJURY; BODY-TEMPERATURE; CARDIAC-SURGERY; BLOOD-PRESSURE; INHIBITORS; KIDNEY; COX-2; COMPLICATIONS; DECREASES; SEVERITY;

D O I：

10.1590/S0102-865020150040000006

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

PURPOSE: To evaluate the effect of parecoxib (an NSAID) on renal function by measuring plasma NGAL (serum neutrophil gelatinase-associated lipocalin) levels in an induced-ischemia rat model. METHODS: Forty male Wistar rats were randomly assigned to one of four groups: Ischemia (I), Ischemia/parecoxib (IP), No-ischemia (NI), and No-ischemia/parecoxib (NIP). Body weight, mean arterial pressure, heart rate, body temperature, NGAL levels, and renal histology were compared across groups. RESULTS: The Ischemia (I) group, which did not receive parecoxib, showed the highest NGAL levels (p=0.001), while the IP group, which received the medication, had NGAL levels similar to those of the non-ischemic (NI and NIP) groups. CONCLUSION: Parecoxib resulted in renal protection in this experimental model.

引用

页码：270 / 275

页数：6

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