Parecoxib reduces renal injury in an ischemia/reperfusion model in rats

被引：9
|
作者：
Calistro Neto, Jose Pedro [1 ]
Torres, Romulo da Costa [1 ]
Goncalves, Giovanna Maria [2 ]
da Silva, Leopoldo Muniz [3 ]
Custodio Domingues, Maria Aparecida [4 ]
Pinheiro Modolo, Norma Sueli [5 ]
Moreira de Barros, Guilherme Antonio [5 ]
机构：
[1] Sao Paulo State Univ, UNESP, Botucatu Med Sch, Postgrad Program Anesthesiol, Sao Paulo, Brazil
[2] UNESP, Botucatu Med Sch, Botucatu, SP, Brazil
[3] UNESP, Botucatu Med Sch, Div Anesthesiol, Botucatu, SP, Brazil
[4] UNESP, Botucatu Med Sch, Dept Pathol, Botucatu, SP, Brazil
[5] UNESP, Botucatu Med Sch, Dept Anesthesiol, Botucatu, SP, Brazil
来源：
ACTA CIRURGICA BRASILEIRA | 2015年 / 30卷 / 04期
关键词：
Parecoxib; Ischemia; Reperfusion; Kidney; Rats; ISCHEMIA-REPERFUSION INJURY; BODY-TEMPERATURE; CARDIAC-SURGERY; BLOOD-PRESSURE; INHIBITORS; KIDNEY; COX-2; COMPLICATIONS; DECREASES; SEVERITY;
D O I：
10.1590/S0102-865020150040000006
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
PURPOSE: To evaluate the effect of parecoxib (an NSAID) on renal function by measuring plasma NGAL (serum neutrophil gelatinase-associated lipocalin) levels in an induced-ischemia rat model. METHODS: Forty male Wistar rats were randomly assigned to one of four groups: Ischemia (I), Ischemia/parecoxib (IP), No-ischemia (NI), and No-ischemia/parecoxib (NIP). Body weight, mean arterial pressure, heart rate, body temperature, NGAL levels, and renal histology were compared across groups. RESULTS: The Ischemia (I) group, which did not receive parecoxib, showed the highest NGAL levels (p=0.001), while the IP group, which received the medication, had NGAL levels similar to those of the non-ischemic (NI and NIP) groups. CONCLUSION: Parecoxib resulted in renal protection in this experimental model.
引用
收藏
页码：270 / 275
页数：6
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