Scaffold hopping in the rational design of novel HIV-1 non-nucleoside reverse transcriptase inhibitors

被引：50

作者：

O'Meara, Jeff A. ^{[1
]}

Jakalian, Araz ^{[1
]}

LaPlante, Steven ^{[1
]}

Bonneau, Pierre R. ^{[1
]}

Coulombe, Rene ^{[1
]}

Faucher, Anne-Marie ^{[1
]}

Guse, Ingrid ^{[1
]}

Landry, Serge ^{[1
]}

Racine, Jennifer ^{[1
]}

Simoneau, Bruno ^{[1
]}

Thavonekham, Bounkham ^{[1
]}

Yoakim, Christiane ^{[1
]}

机构：

[1] Boehringer Ingelheim Ltd, Res & Dev, Laval, PQ H7S 2G5, Canada

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 12期

关键词：

NNRTI; scaffold hopping; tertiary amide; tertiary carbamate; thio-tetrazole; tetrazole thioacetanilide;

D O I：

10.1016/j.bmcl.2007.03.097

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

High-throughput screening hit 1 was identified as a potent, broad-spectrum, non-nucleoside reverse transcriptase inhibitor (NNRTI) of HIV-1 replication. Analysis of the bound conformation of analogs of this inhibitor via molecular modeling and NMR contributed to the design of novel tertiary amide, carbamate, and thiocarbamate based NNRTIs. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：3362 / 3366

页数：5

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