Systematic investigation of non-nucleoside inhibitors of HIV-1 reverse transcriptase (NNRTIs)

被引：6
|
作者：
Beyer, A
Lawtrakul, L
Hannongbua, S
Wolschann, P
机构：
[1] Res Inst Mol Pathol, A-1030 Vienna, Austria
[2] Thammasat Univ, SIIT, Dept Common & Grad Studies, Pathum Thani 12121, Thailand
[3] Kasetsart Univ, Fac Sci, Dept Chem, Bangkok 10900, Thailand
[4] Inst Theoret Chem & Struct Biol, A-1090 Vienna, Austria
来源：
MONATSHEFTE FUR CHEMIE | 2004年 / 135卷 / 08期
关键词：
non-nucleoside reverse transcriptase inhibitors (NNRTIs); inhibition mechanism; viral mutation; drug resistance;
D O I：
10.1007/s00706-004-0173-y
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The 44 crystal structures of NNRTIs complexed with HIV-1 reverse transcriptase (RT) have been analyzed in detail especially the orientation geometries and the distances between inhibitor molecules and surrounding amino acids. In general, various NNIs bind to the same region of the HIV-1 RT in the palm subdomain of p66, but subtle differences in individual interactions between RT and its inhibitors can be detected by comparison of all structures in this study.
引用
收藏
页码：1047 / 1059
页数：13
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