WAY-100635 reverses 8-OH-DPAT-induced performance impairment in the radial maze

被引：15
|
作者：
Helsley, S [1 ]
Siegel, TL [1 ]
Fiorella, D [1 ]
Rabin, RA [1 ]
Winter, JC [1 ]
机构：
[1] SUNY Buffalo, Sch Med & Biomed Sci, Dept Pharmacol & Toxicol, Buffalo, NY 14214 USA
来源：
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 1998年 / 22卷 / 07期
关键词：
learning and memory; radial maze; serotonin;
D O I：
10.1016/S0278-5846(98)00068-2
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
1. The effects of the 5-HT1A receptor agonist, (8-OH-DPAT), alone and in combination with the selective 5-HT1A antagonist, WAY-100635, were assessed in Fischer-344 rats in an 8-arm radial maze. 2. At a dose of 1.0 mg/kg, 8-OH-DPAT significantly reduced both efficiency of performance (% correct arm entries) and response rate (arms/min) compared with the saline condition. 3, These effects were completely blocked by WAY-100635 which by itself had no effect on efficiency or response Fate. 4. WAY-100635 inhibits 8-OH-DPAT-induced impairment in radial maze performance.
引用
收藏
页码：1179 / 1184
页数：6
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