Rh(I)-Catalyzed Formal [5+1]/[2+2+1] Cycloaddition of 1-Yne-vinylcyclopropanes and Two CO Units: One-Step Construction of Multifunctional Angular Tricyclic 5/5/6 Compounds

被引：80

作者：

Lin, Mu ^{[1
]}

Li, Feng ^{[1
]}

Jiao, Lei ^{[1
]}

Yu, Zhi-Xiang ^{[1
]}

机构：

[1] Peking Univ, BNLMS, Key Lab Bioorgan Chem & Mol Engn, Minist Educ,Coll Chem, Beijing 100871, Peoples R China

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2011年 / 133卷 / 06期

关键词：

PAUSON-KHAND REACTION; CARBONYLATIVE CARBOTRICYCLIZATION; ATOM ECONOMY; ENEDIYNES; MECHANISM; CATALYSIS; ALKYNES;

D O I：

10.1021/ja110039h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel Rh(I)-catalyzed formal [5 + 1]/[2 + 2 + 1] cycloaddition of 1-yne-vinylcydopropanes and two CO units for the construction of multifunctional angular tricyclic 5/5/6 skeletons with one or two adjacent bridgehead quaternary all-carbon stereocenters in one step has been developed. Preliminary density functional theory calculations have been carried out to investigate the reaction mechanism and the substituent effects.

引用

页码：1690 / 1693

页数：4

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