Rh(I)-Catalyzed Formal [5+1]/[2+2+1] Cycloaddition of 1-Yne-vinylcyclopropanes and Two CO Units: One-Step Construction of Multifunctional Angular Tricyclic 5/5/6 Compounds

被引：80
|
作者：
Lin, Mu [1 ]
Li, Feng [1 ]
Jiao, Lei [1 ]
Yu, Zhi-Xiang [1 ]
机构：
[1] Peking Univ, BNLMS, Key Lab Bioorgan Chem & Mol Engn, Minist Educ,Coll Chem, Beijing 100871, Peoples R China
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2011年 / 133卷 / 06期
关键词：
PAUSON-KHAND REACTION; CARBONYLATIVE CARBOTRICYCLIZATION; ATOM ECONOMY; ENEDIYNES; MECHANISM; CATALYSIS; ALKYNES;
D O I：
10.1021/ja110039h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel Rh(I)-catalyzed formal [5 + 1]/[2 + 2 + 1] cycloaddition of 1-yne-vinylcydopropanes and two CO units for the construction of multifunctional angular tricyclic 5/5/6 skeletons with one or two adjacent bridgehead quaternary all-carbon stereocenters in one step has been developed. Preliminary density functional theory calculations have been carried out to investigate the reaction mechanism and the substituent effects.
引用
收藏
页码：1690 / 1693
页数：4
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