In(OTf)3 catalysed an expeditious synthesis of β-carboline-imidazo[1,2-a]pyridine and imidazo[1,2-a]pyrazine conjugates

被引：31

作者：

Devi, Nisha ^{[1
]}

Singh, Dharmender ^{[1
]}

Honey ^{[1
]}

Mor, Satbir ^{[2
]}

Chaudhary, Sandeep ^{[3
]}

Rawal, Ravindra K. ^{[4
]}

Kumar, Vipin ^{[1
]}

Chowdhury, Asim K. ^{[1
]}

Singh, Virender ^{[1
]}

机构：

[1] Dr BR Ambedkar Natl Inst Technol NIT Jalandhar, Dept Chem, Jalandhar 144011, Punjab, India

[2] GJ Univ Sci & Technol Hisar, Dept Chem, Hisar 125001, Haryana, India

[3] Malaviya Natl Inst Technol Jaipur MNIT, Dept Chem, Jaipur 302017, Rajasthan, India

[4] Indosoviet Friendship Coll Pharm, Dept Pharmaceut Chem, Moga 142001, Punjab, India

来源：

RSC ADVANCES | 2016年 / 6卷 / 50期

关键词：

NONREARRANGED MONOTERPENOID UNIT; SIMPLE INDOLE ALKALOIDS; BETA-CARBOLINE DERIVATIVES; EUKARYOTIC TOPOISOMERASE-II; BLACKBURN-BIENAYME REACTION; SOLVENT-FREE CONDITIONS; BIOLOGICAL EVALUATION; ANTITUMOR AGENTS; INDIUM TRIFLATE; ANTICANCER ACTIVITY;

D O I：

10.1039/c6ra04841b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

beta-Carboline containing alkaloids are ubiquitously present in Nature, while imidazo[1,2-a]pyridine nucleus is incorporated in various synthetic commercial drugs and biologically previliged moieties. On this basis, new beta-carboline-imidazoazine conjugates were designed and a small library of compounds integrating both the pharmacophores was constructed with 4-points of diversity by using the In(OTf)(3) assisted Groebke-Blackburn-Bienayme multicomponent strategy. The methodology was found to be simple and convenient for the efficient syntheses of beta-carboline-imidazo[1,2-a]azine conjugates. The present synthetic protocol provides several advantages like operational simplicity, appreciable atom economy, short reaction time and easy purification procedure.

引用

页码：43881 / 43891

页数：11

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