A general synthesis of (+/-)-dibenzocyclooctadiene lignans

被引：0

作者：

Takeya, T ^{[1
]}

Yamaki, S ^{[1
]}

Itoh, T ^{[1
]}

Hosogai, H ^{[1
]}

Tobinaga, S ^{[1
]}

机构：

[1] SHOWA COLL PHARMACEUT SCI, MACHIDA, TOKYO 194, JAPAN

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1996年 / 44卷 / 05期

关键词：

general synthesis lignan; dibenzocyclooctadiene; spirodienone ether; Weitz' aminium salt; oxidative aryl-aryl coupling;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We have established a new general synthesis for (+/-)-dibenzocyclooctadiene lignans, including(+/-)-schizandrin (1a), (+/-)-gomisin A (1b), (+/-)-isoschizandrin (3a), and (+/-)-isogomisin A (3b), via the spiro-dienone ethers E- and T-11 as the key intermediates, prepared from the corresponding gisarylbutanol derivatives E- and T-10 by the oxidation with Weitz' aminium salt, tris(4-bromophenyl)aminium hexachloroantimonate (BAHA). These syntheses consist of 13 steps from the phenylpropanone 5.

引用

页码：909 / 918

页数：10

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