A general synthesis of (+/-)-dibenzocyclooctadiene lignans

被引：0
|
作者：
Takeya, T [1 ]
Yamaki, S [1 ]
Itoh, T [1 ]
Hosogai, H [1 ]
Tobinaga, S [1 ]
机构：
[1] SHOWA COLL PHARMACEUT SCI, MACHIDA, TOKYO 194, JAPAN
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 1996年 / 44卷 / 05期
关键词：
general synthesis lignan; dibenzocyclooctadiene; spirodienone ether; Weitz' aminium salt; oxidative aryl-aryl coupling;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
We have established a new general synthesis for (+/-)-dibenzocyclooctadiene lignans, including(+/-)-schizandrin (1a), (+/-)-gomisin A (1b), (+/-)-isoschizandrin (3a), and (+/-)-isogomisin A (3b), via the spiro-dienone ethers E- and T-11 as the key intermediates, prepared from the corresponding gisarylbutanol derivatives E- and T-10 by the oxidation with Weitz' aminium salt, tris(4-bromophenyl)aminium hexachloroantimonate (BAHA). These syntheses consist of 13 steps from the phenylpropanone 5.
引用
收藏
页码：909 / 918
页数：10
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