STAT5B, the dominant twin, in hematopoietic stem cells

被引：0

作者：

Chen, Yuhong ^{[1
]}

Wang, Demin ^{[1
]}

机构：

[1] Versiti Blood Res Inst, Wauwatosa, WI 53226 USA

来源：

BLOOD | 2021年 / 138卷 / 23期

关键词：

D O I：

10.1182/blood.2021013532

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In this issue of Blood, Kollmann et al used single-cell RNA sequencing (scRNAseq) to identify a unique and dominant role for STAT5B in self-renewal of hematopoietic stem cells (HSCs) and leukemia stem cells (LSCs). Moreover, they found that the cell surface marker CD9 is an important STAT5B target gene, implicating CD9 as a novel therapeutic target for STAT5-driven leukemia.

引用

页码：2303 / 2305

页数：3

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