STAT5B, the dominant twin, in hematopoietic stem cells

被引：0
|
作者：
Chen, Yuhong [1 ]
Wang, Demin [1 ]
机构：
[1] Versiti Blood Res Inst, Wauwatosa, WI 53226 USA
来源：
BLOOD | 2021年 / 138卷 / 23期
关键词：
D O I：
10.1182/blood.2021013532
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In this issue of Blood, Kollmann et al used single-cell RNA sequencing (scRNAseq) to identify a unique and dominant role for STAT5B in self-renewal of hematopoietic stem cells (HSCs) and leukemia stem cells (LSCs). Moreover, they found that the cell surface marker CD9 is an important STAT5B target gene, implicating CD9 as a novel therapeutic target for STAT5-driven leukemia.
引用
收藏
页码：2303 / 2305
页数：3
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