Synthesis of a pyrrolo[1,4]benzodiazepinequinone

被引：8
|
作者：
Tapia, RA [1 ]
Centella, CR [1 ]
Valderrama, JA [1 ]
机构：
[1] Pontificia Univ Catolica Chile, Fac Quim, Santiago 22, Chile
来源：
SYNTHETIC COMMUNICATIONS | 1999年 / 29卷 / 12期
关键词：
D O I：
10.1080/00397919908086212
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Condensation of 3,6-dimethoxy-2-nitrobenzoyl chloride with L-proline methyl ester afforded amide 4, which underwent reductive cyclization with iron(II) sulfate and ammonium hydroxide to yield pyrrolobenzodiazepine 5. Oxidation of 5 with ammonium cerium(IV) nitrate led to the new heterocyclic quinone 6 in 53% overall yield.
引用
收藏
页码：2163 / 2168
页数：6
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