Synthesis of a pyrrolo[1,4]benzodiazepinequinone

被引：8

作者：

Tapia, RA ^{[1
]}

Centella, CR ^{[1
]}

Valderrama, JA ^{[1
]}

机构：

[1] Pontificia Univ Catolica Chile, Fac Quim, Santiago 22, Chile

来源：

SYNTHETIC COMMUNICATIONS | 1999年 / 29卷 / 12期

关键词：

D O I：

10.1080/00397919908086212

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Condensation of 3,6-dimethoxy-2-nitrobenzoyl chloride with L-proline methyl ester afforded amide 4, which underwent reductive cyclization with iron(II) sulfate and ammonium hydroxide to yield pyrrolobenzodiazepine 5. Oxidation of 5 with ammonium cerium(IV) nitrate led to the new heterocyclic quinone 6 in 53% overall yield.

引用

页码：2163 / 2168

页数：6

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