Serological responses to COVID-19 Comirnaty booster vaccine, London, United Kingdom, September to December 2021

被引：5

作者：

Ireland, Georgina ^{[1
]}

Whitaker, Heather ^{[2
]}

Ladhani, Shamez N. ^{[1
,7
]}

Baawuah, Frances ^{[1
,3
]}

Subbarao, Sathyvani ^{[1
]}

Linley, Ezra ^{[4
]}

Warrener, Lenesha ^{[5
]}

O'Brien, Michelle ^{[3
]}

Whillock, Corinne ^{[1
]}

Martin, Oliver ^{[1
]}

Moss, Paul ^{[6
]}

Ramsay, Mary E. ^{[1
]}

Amirthalingam, Gayatri ^{[1
]}

Brown, Kevin E. ^{[1
]}

机构：

[1] UK Hlth Secur Agcy, Immunisat & Vaccine Preventable Dis Div, London, England

[2] UK Hlth Secur Agcy, Stat Modelling & Econ Dept, London, England

[3] Kilburn, Brondesbury Med Ctr, London, England

[4] UK Hlth Secur Agcy, Seroepidemiol Unit, Manchester, Lancs, England

[5] UK Hlth Secur Agcy, Virus Reference Dept, London, England

[6] Univ Birmingham, Inst Immunol & Immunotherapy, Edgbaston, England

[7] St Georges Univ London, Paediat Infect Dis Res Grp, London, England

来源：

EUROSURVEILLANCE | 2022年 / 27卷 / 01期

关键词：

D O I：

10.2807/1560-7917.ES.2022.27.1.2101114

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Serum samples were collected pre- and post-booster vaccination with Comirnaty in 626 participants (aged >= 50 years) who had received two Comirnaty doses<30 days apart, two Comirnaty dosesa >= 30 days apart or two Vaxzevria doses >= 30 days apart. Irrespective of primary vaccine type or schedule, spike antibody GMTs peaked 2-4 weeks after second dose, fell significantly <= 38 weeks later and rose above primary immunisation GMTs 2-4 weeks post-booster. Higher post-booster responses were observed with a longer interval between primary immunisation and boosting.

引用

页数：7

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