Iron overload in myelodysplastic syndromes: A Canadian consensus guideline

被引：40

作者：

Wells, Richard A. ^{[1
]}

Leber, Brian ^{[2
,3
]}

Buckstein, Rena ^{[1
]}

Lipton, Jeffrey H. ^{[4
]}

Hasegawa, Wanda ^{[5
]}

Grewal, Kujit ^{[6
]}

Yee, Karen ^{[4
]}

Olney, Harold J. ^{[7
]}

Larratt, Loree ^{[8
]}

Vickars, Linda ^{[9
]}

Tinmouth, Alan ^{[10
]}

机构：

[1] Sunnybrook Hlth Sci Ctr, Odette Canc Ctr, Myelodysplast Syndromes Program, Toronto, ON M4N 3M5, Canada

[2] Hamilton Hlth Sci, Hamilton, ON, Canada

[3] McMaster Univ, Hamilton, ON, Canada

[4] Princess Margaret Hosp, Univ Hlth Network, Toronto, ON M4X 1K9, Canada

[5] Queen Elizabeth 2 Hlth Sci Ctr, Halifax, NS, Canada

[6] Hlth Sci Ctr, St John, NF, Canada

[7] Hop Notre Dame de Bon Secours, CHU Montreal, Montreal, PQ H2L 4K8, Canada

[8] Univ Alberta, Edmonton, AB, Canada

[9] BC Canc Agcy, Vancouver, BC, Canada

[10] Ottawa Hosp, Ottawa, ON, Canada

来源：

LEUKEMIA RESEARCH | 2008年 / 32卷 / 09期

关键词：

myelodysplastic syndromes; iron overload; secondary hemosiderosis; iron chelation; deferoxamine; deferasirox; desferal; exjade; deferriprone; ferriprox; transfusion; prognosis; guideline;

D O I：

10.1016/j.leukres.2008.02.021

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In December 2005, 11 Canadian hematologists met to develop an evidence-based clinical practice guideline that would address the diagnosis, monitoring, management, and rationale for the treatment of transfusional iron overload in patients with myelodysplastic syndromes (MDS). This Expert Panel consisted of hematologists from across Canada, each with an active practice in a major population centre or a rural area. Based on an extensive literature search and years of clinical experience, their mandate was to address common clinical practice questions, particularly why treat, whom to treat, when to initiate treatment, and how to treat iron overload in patients with MDS. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：1338 / 1353

页数：16

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