Cardiac iron overload in transfusion-dependent patients with myelodysplastic syndromes

被引：46
|
作者：
Roy, Noemi B. A. [1 ]
Myerson, Saul [2 ]
Schuh, Anna H. [3 ]
Bignell, Patricia [3 ]
Patel, Roger [4 ]
Wainscoat, Jim S. [5 ]
McGowan, Simon [6 ]
Marchi, Emanuele [6 ]
Atoyebi, Wale [5 ]
Littlewood, Tim [5 ]
Chacko, Joseph [7 ]
Vyas, Paresh
Killick, Sally B. [7 ]
机构：
[1] John Radcliffe Hosp, Weatherall Inst Mol Med, Mol Haematol Unit, Oxford OX3 9DS, England
[2] Oxford Radcliffe Hosp, Dept Cardiol, Oxford, England
[3] Oxford Radcliffe Hosp, Haemato Mol Diagnost Serv, Oxford, England
[4] Royal Bournemouth Hosp, Dept Radiol, Bournemouth, Dorset, England
[5] Oxford Radcliffe Hosp, Dept Haematol, Oxford, England
[6] Weatherall Inst Mol Med, Computat Biol Res Grp, Oxford, England
[7] Royal Bournemouth Hosp, Dept Haematol, Bournemouth, Dorset, England
来源：
BRITISH JOURNAL OF HAEMATOLOGY | 2011年 / 154卷 / 04期
关键词：
myelodysplastic syndromes; magnetic resonance imaging; transfusional iron overload; hepatic R2*; cardiac R2*; MAGNETIC-RESONANCE; MYOCARDIAL IRON; ACQUIRED ANEMIAS; THALASSEMIA; CHELATION; DISEASE;
D O I：
10.1111/j.1365-2141.2011.08749.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Transfusion- dependent myelodysplastic (MDS) patients are prone to iron overload. We evaluated 43 transfused MDS patients with T2* magnetic resonance imaging scans. 81% had liver and 16.8% cardiac iron overload. Liver R2* (1000/T2*), but not cardiac R2*, was correlated with number of units transfused (r = 0.72, P < 0.0001) and ferritin (r = 0.53, P < 0.0001). The area under the curve of a time-ferritin plot was found to be much greater in patients with cardiac iron loading (median 53.7 x 10(5) Megaunits vs. 12.2 x 10(5) Megaunits, P = 0.002). HFE, HFE2, HAMP or SLC40A1 genotypes were not predictors of iron overload in these patients.
引用
收藏
页码：521 / 524
页数：4
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