A New Series of 1,3,4-Oxadiazole Linked Quinolinyl-Pyrazole/Isoxazole Derivatives: Synthesis and Biological Activity Evaluation

被引：4

作者：

Basavanna, V ^{[1
]}

Chandramouli, M. ^{[1
]}

Kempaiah, C. ^{[2
]}

Bhadraiah, U. K. ^{[3
]}

Chandra ^{[4
]}

Lingegowda, N. S. ^{[1
]}

Doddamani, Shridevi ^{[5
]}

Ningaiah, S. ^{[1
]}

机构：

[1] Visvesvaraya Technol Univ, Vidyavardhaka Coll Engn, Dept Chem, Mysore 570002, Karnataka, India

[2] HKBK Coll Engn, Dept Engn Phys, Bengaluru 560045, Karnataka, India

[3] Univ Mysore, Yuvarajas Coll, Dept Chem, Mysore 570005, Karnataka, India

[4] Natl Inst Engn NIE, Dept Phys, Mysore 570008, Karnataka, India

[5] CSIR NIIST, Chem Sci & Technol Div, Thiruvananthapuram 695019, Kerala, India

来源：

RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2021年 / 91卷 / 11期

关键词：

1; 3; 4-oxadiazole; pyrazole; isoxazole; quinoline; molecular docking; antimicrobial; anti-inflammatory;

D O I：

10.1134/S1070363221110128

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of 1,3,4-oxadiazole bridged pyrazole/isoxazole bearing quinoline derivatives has been designed and synthesized by a clean and convenient method. Structures of the newly synthesized compounds have been confirmed by FTIR, H-1 and C-13 NMR, and HRMS spectral data. The titled compounds have been evaluated for their molecular docking guided antimicrobial and anti-inflammatory activity. One of 1,3,4-oxadiazole bridged quinolinyl-pyrazole derivatives has interacted efficiently with E. Coli protein (PDB file: 1KZN), and has been characterized by good antimicrobial activity against the majority of the tested pathogens. Another product has exhibited excellent anti-inflammatory activity.

引用

页码：2257 / 2266

页数：10

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