Synthesis of substituted 1,3,4-oxadiazole derivatives

被引：0
|
作者：
V. Mickevičius
R. Vaickelionienė
B. Sapijanskaitė
机构：
[1] Kaunas University of Technology,
来源：
Chemistry of Heterocyclic Compounds | 2009年 / 45卷
关键词：
acid hydrazides; benzoyl chloride; 2-pyrrolidinone; substituted oxadiazoles; thionyl chloride; 5-thioxo-1,3,4-oxadiazoles;
D O I：
暂无
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学科分类号：
摘要：
Monosubstituted oxadiazoles were synthesized by the reaction of hydrazides with triethyl orthoformate. Their reactions with benzoyl chloride gave benzoylcarbohydrazides, which under the action of thionyl chloride were cyclized to the respective 2,5-disubstituted oxadiazoles. 1-Aryl-4-(5-thioxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)-pyrrolidin-2-ones were synthesized from acid hydrazides using carbon disulfide under basic conditions.
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页码：215 / 218
页数：3
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