EFFICIENT SYNTHESIS OF NEW FUNCTIONALIZED 2-(HETARYL)THIAZOLES

被引：16

作者：

Bondock, Samir ^{[1
,2
]}

El-Azab, Hossam ^{[1
]}

Kandeel, Ez-Eldin M. ^{[1
]}

Metwally, Mohamed A. ^{[1
]}

机构：

[1] Mansoura Univ, Dept Chem, Fac Sci, ET-35516 Mansoura, Egypt

[2] King Khalid Univ, Dept Chem, Fac Sci, Abha, Saudi Arabia

来源：

SYNTHETIC COMMUNICATIONS | 2013年 / 43卷 / 01期

关键词：

Japp-Klingmann; phenyl isothiocyanate; pyrazole; pyridine; thiazole; THIAZOLE; HETEROCYCLES; DERIVATIVES; ETHYL;

D O I：

10.1080/00397911.2011.591036

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient synthesis of the hitherto unknown ring system, 2-heteroaryl-thiazoles, is described via the reaction of 3-oxo-N-(4-phenylthiazol-2-yl) butanamide (1) with diazotized heterocyclic amine, phenyl isothiocyanate, dimethylformamide-dimethylacetal, and hydrazine hydrate, and the reaction of 2-chloro-N-(4-phenylthiazol-2-yl) acetamide (13) with some sulfur nucleophiles and malononitrile. The structures of the compounds prepared were determined by analytical and spectral analyses.

引用

页码：59 / 71

页数：13

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