Synthesis and analgesic activity of some new benzoyl derivatives

被引：0
|
作者：
Gupta, Sumit [1 ]
Pandeya, Surendra N.
Kumar, Praveen
Tripathi, Laxmi
Anurag, Prince Prashant
Verma, Krishna
机构：
[1] Dr KN Modi Inst Pharmaceut Educ & Res, Dept Pharmaceut Chem, Modinagar 201201, India
[2] Fac Pharm, Dept Pharmaceut Chem, New Delhi 110062, India
来源：
ASIAN JOURNAL OF CHEMISTRY | 2007年 / 19卷 / 04期
关键词：
synthesis; benzoyl derivatives; analgesic activity;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(+/-) Menthol (1) was oxidized to menthone (2) which was reacted with hydroxylamine hydrochloride to yield menthone oxime (3). The menthone oxime (3) was converted to (2s, 5r)-(+/-)-2-isopropyl-5-methyl-1-azacycloheptane-7-one (4) via Schmidt reaction, which was reacted with various substituted aromatic benzoyl chlorides in alkaline medium to yield various phenyl substituted 1-benzoyl-7-isopropyl-4-methylazepan-2-one derivatives (5a-g). The structure of newly synthesized compounds have been established by analytical and spectral methods. These compounds have also been screened for analgesic activity.
引用
收藏
页码：2891 / 2895
页数：5
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