Synthesis and analgesic activity of some new benzoyl derivatives

被引：0
|
作者：
Gupta, Sumit [1 ]
Pandeya, Surendra N.
Kumar, Praveen
Tripathi, Laxmi
Anurag, Prince Prashant
Verma, Krishna
机构：
[1] Dr KN Modi Inst Pharmaceut Educ & Res, Dept Pharmaceut Chem, Modinagar 201201, India
[2] Fac Pharm, Dept Pharmaceut Chem, New Delhi 110062, India
来源：
ASIAN JOURNAL OF CHEMISTRY | 2007年 / 19卷 / 04期
关键词：
synthesis; benzoyl derivatives; analgesic activity;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(+/-) Menthol (1) was oxidized to menthone (2) which was reacted with hydroxylamine hydrochloride to yield menthone oxime (3). The menthone oxime (3) was converted to (2s, 5r)-(+/-)-2-isopropyl-5-methyl-1-azacycloheptane-7-one (4) via Schmidt reaction, which was reacted with various substituted aromatic benzoyl chlorides in alkaline medium to yield various phenyl substituted 1-benzoyl-7-isopropyl-4-methylazepan-2-one derivatives (5a-g). The structure of newly synthesized compounds have been established by analytical and spectral methods. These compounds have also been screened for analgesic activity.
引用
收藏
页码：2891 / 2895
页数：5
相关论文
共 50 条
  • [1] Synthesis and analgesic activity of some new phenyl sulfonyl derivatives
    Gupta, Sumit
    Pandeya, Surendpa N.
    Kumar, Praveen
    Tripathi, Laxmi
    [J]. ASIAN JOURNAL OF CHEMISTRY, 2007, 19 (04) : 2818 - 2822
  • [2] SYNTHESIS OF NEW BENZOYL DERIVATIVES OF SOME INDOLES
    SAMSONIYA, SA
    CHIKVAIDZE, IS
    GOGRICHIANI, EO
    LOMADZE, NS
    TARGAMADZE, NL
    [J]. KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII, 1994, (09): : 1202 - 1205
  • [3] Synthesis and analgesic activity of some acetamide derivatives
    Kaplancikli, Zafer Asim
    Altintop, Mehlika Dilek
    Turan-Zitouni, Gulhan
    Ozdemir, Ahmet
    Can, Ozgur Devrim
    [J]. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2012, 27 (02) : 275 - 280
  • [4] SYNTHESIS AND ANALGESIC ACTIVITY OF NEW PHENCYCLIDINE DERIVATIVES
    ALDEEB, OA
    [J]. ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH, 1994, 44-2 (10): : 1141 - 1144
  • [5] Synthesis and analgesic activity evaluation of some agmatine derivatives
    He, Hongxia
    Liu, Mengjia
    Zheng, Zhibing
    Liu, Ying
    Xiao, Junhai
    Su, Ruibin
    Hu, Chun
    Li, Jin
    Li, Song
    [J]. MOLECULES, 2006, 11 (06) : 393 - 402
  • [6] Synthesis and analgesic activity of some deaza derivatives of anpirtoline
    Rádl, S
    Hezky, P
    Proska, J
    Krejcí, I
    [J]. ARCHIV DER PHARMAZIE, 1999, 332 (01) : 13 - 18
  • [7] Synthesis and antiinflammatory activity of some new derivatives of 6-benzoyl-1,4-benzodioxane
    Labanauskas L.K.
    Brukshtus A.B.
    Gaidelis P.G.
    Udrenaite É.B.
    Daukshas V.K.
    [J]. Pharmaceutical Chemistry Journal, 1999, 33 (5) : 259 - 260
  • [8] Synthesis, antiinflammatory and analgesic activity of new hexahydropyrimidine derivatives
    Khan, MSY
    Gupta, M
    [J]. PHARMAZIE, 2002, 57 (06): : 377 - 383
  • [9] SYNTHESIS OF SOME BENZOFURAN-CARBOXAMIDE DERIVATIVES AND THEIR ANALGESIC ACTIVITY
    HISMAT, OH
    HASHIM, AA
    SHALASH, MR
    NAWITO, M
    [J]. ARZNEIMITTEL-FORSCHUNG, 1971, 21 (07): : 1026 - &
  • [10] Synthesis and Analgesic Activity of New Heterocyclic Cyanothioacetamide Derivatives
    Bibik, I. V.
    Bibik, E. Yu.
    Dotsenko, V. V.
    Frolov, K. A.
    Krivokolysko, S. G.
    Aksenov, N. A.
    Aksenova, I. V.
    Shcherbakov, S. V.
    Ovcharov, S. N.
    [J]. RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2021, 91 (02) : 154 - 166
12345