SYNTHESIS AND ANALGESIC ACTIVITY OF NEW PHENCYCLIDINE DERIVATIVES

被引：0
|
作者：
ALDEEB, OA
机构：
来源：
ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH | 1994年 / 44-2卷 / 10期
关键词：
ANALGESICS; PHENCYCLIDINE DERIVATIVES; PHARMACOLOGY; SYNTHESIS;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
New phencyclidine derivatives having structural similarities with the well known 4-phenylpiperidine narcotic analgesics were synthesized, characterized and their antinociceptive activity tested in mice by the hot-plate and tail-flick tests. Structure-activity relationships for these compounds further point to the importance of a second aryl moiety at position 4 of the piperidine ring of phencyclidine. In addition, the presence of a hydroxyl group in close proximate to the lipophilic moiety is vital for analgesic activity.
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页码：1141 / 1144
页数：4
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