Reference Geometry-based Detection of (4D-)CT Motion Artifacts: a Feasibility Study

Respiration-correlated computed tomography (4D or 3D+ t CT) can be considered as standard of care in radiation therapy treatment planning for lung and liver lesions. The decision about an application of motion management devices and the estimation of patient-specific motion effects on the dose distribution relies on precise motion assessment in the planning 4D CT data - which is impeded in case of CT motion artifacts. The development of image-based/post-processing approaches to reduce motion artifacts would bene fi t from precise detection and localization of the artifacts. Simple slice-by-slice comparison of intensity values and threshold-based analysis of related metrics suffer from - depending on the threshold - high false-positive or -negative rates. In this work, we propose exploiting prior knowledge about 'ideal' (= artifact free) reference geometries to stabilize metric-based artifact detection by transferring (multi-) atlas-based concepts to this specific task. Two variants are introduced and evaluated: (S1) analysis and comparison of warped atlas data obtained by repeated non-linear atlas-to-patient registration with different levels of regularization; (S2) direct analysis of vector field properties (divergence, curl magnitude) of the atlas-to-patient transformation. Feasibility of approaches (S1) and (S2) is evaluated by motion-phantom data and intra-subject experiments (four patients) as well as - adopting a multi-atlas strategy - inter-subject investigations (twelve patients involved). It is demonstrated that especially sorting/double structure artifacts can be precisely detected and localized by (S1). In contrast, (S2) suffers from high false positive rates.