Fluorined Mono-carbonyl Curcumin Analogues Induce Reactive Oxygen Species to Enhance Apoptosis in Human Colon Cancer HCT116 Cells

被引：0
|
作者：
Mu, Wen-Wen [1 ]
Cao, Yu-Xin [1 ]
Tie, Xiao-Ru [1 ]
Li, Ting [1 ]
Zhu, Zhen-Zhen [1 ]
Yang, Jie [1 ]
Liu, Guo-Yun [1 ]
机构：
[1] Liaocheng Univ, Sch Pharm, 1 Hunan St, Liaocheng 252000, Shandong, Peoples R China
来源：
LATIN AMERICAN JOURNAL OF PHARMACY | 2020年 / 39卷 / 02期
基金：
中国国家自然科学基金;
关键词：
apoptosis; colon cancer; mono-carbonyl curcumin; reactive oxygen species; MEDICINAL-PLANTS; MEDIATED APOPTOSIS; COLORECTAL-CANCER; ANTICANCER; DRUG;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Mono-carbonyl curcumin (MAC), the curcumin-inspired anticancer agent, has shown potent stability and potential anti-proliferation in vitro activity. Colon cancer is one of the leading cause of cancers deaths in the world. Fluorined MACs (la) exhibited potent apoptosis activity in lung cancer cells. In order to develop new cytotoxic agents for colon cancer, we investigated the anticancer effects and the underlying mechanism of la in colon cancers. Fluorined MACs showed an equal or more potent cytotoxic than curcumin. la could induce apoptosis of HCT116 cells through the generation of reactive oxygen species (ROS) and collapse of mitochondrial membrane potential. These results indicated that targeting ROS production could be a potent pathway for the expansion of new anti-colon cancer agents.
引用
收藏
页码：361 / 365
页数：5
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