Fluorined Mono-carbonyl Curcumin Analogues Induce Reactive Oxygen Species to Enhance Apoptosis in Human Colon Cancer HCT116 Cells

被引：0
|
作者：
Mu, Wen-Wen [1 ]
Cao, Yu-Xin [1 ]
Tie, Xiao-Ru [1 ]
Li, Ting [1 ]
Zhu, Zhen-Zhen [1 ]
Yang, Jie [1 ]
Liu, Guo-Yun [1 ]
机构：
[1] Liaocheng Univ, Sch Pharm, 1 Hunan St, Liaocheng 252000, Shandong, Peoples R China
来源：
LATIN AMERICAN JOURNAL OF PHARMACY | 2020年 / 39卷 / 02期
基金：
中国国家自然科学基金;
关键词：
apoptosis; colon cancer; mono-carbonyl curcumin; reactive oxygen species; MEDICINAL-PLANTS; MEDIATED APOPTOSIS; COLORECTAL-CANCER; ANTICANCER; DRUG;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Mono-carbonyl curcumin (MAC), the curcumin-inspired anticancer agent, has shown potent stability and potential anti-proliferation in vitro activity. Colon cancer is one of the leading cause of cancers deaths in the world. Fluorined MACs (la) exhibited potent apoptosis activity in lung cancer cells. In order to develop new cytotoxic agents for colon cancer, we investigated the anticancer effects and the underlying mechanism of la in colon cancers. Fluorined MACs showed an equal or more potent cytotoxic than curcumin. la could induce apoptosis of HCT116 cells through the generation of reactive oxygen species (ROS) and collapse of mitochondrial membrane potential. These results indicated that targeting ROS production could be a potent pathway for the expansion of new anti-colon cancer agents.
引用
收藏
页码：361 / 365
页数：5
相关论文
共 50 条
  • [21] Marine Peroxy Sesquiterpenoids Induce Apoptosis by Modulation of Nrf2-ARE Signaling in HCT116 Colon Cancer Cells
    Taira, Junsei
    Miyazato, Haruna
    Ueda, Katsuhiro
    MARINE DRUGS, 2018, 16 (10):
  • [22] DZNep inhibits the proliferation of colon cancer HCT116 cells by inducing senescence and apoptosis
    Sha, Mingquan
    Mao, Genxiang
    Wang, Guofu
    Chen, Yufeng
    Wu, Xiaojian
    Wang, Zhen
    ACTA PHARMACEUTICA SINICA B, 2015, 5 (03) : 188 - 193
  • [23] Curcuminoids Induce Reactive Oxygen Species and Autophagy to Enhance Apoptosis in Human Oral Cancer Cells
    Hsiao, Yung-Ting
    Kuo, Chao-Lin
    Chueh, Fu-Shin
    Liu, Kuo-Ching
    Bau, Da-Tian
    Chung, Jing-Gung
    AMERICAN JOURNAL OF CHINESE MEDICINE, 2018, 46 (05): : 1145 - 1168
  • [24] DZNep inhibits the proliferation of colon cancer HCT116 cells by inducing senescence and apoptosis
    Mingquan Sha
    Genxiang Mao
    Guofu Wang
    Yufeng Chen
    Xiaojian Wu
    Zhen Wang
    ActaPharmaceuticaSinicaB, 2015, 5 (03) : 188 - 193
  • [25] Polyamines as antioxidants in human colon cancer cells (HCT116) in culture.
    Edwards, CR
    Zwingmann, WC
    Slattery, SJ
    Osborne, DL
    FASEB JOURNAL, 2001, 15 (04): : A84 - A84
  • [26] Curcumin induces c-jun N-terminal kinase-dependent apoptosis in HCT116 human colon cancer cells
    Collett, GP
    Campbell, FC
    CARCINOGENESIS, 2004, 25 (11) : 2183 - 2189
  • [27] Cotinine alters growth of human colon cancer cells (HCT116) in culture
    Osborne, DL
    Benefield, RW
    Davis, J
    FASEB JOURNAL, 2002, 16 (05): : A1153 - A1153
  • [28] Apigenin-induced apoptosis is enhanced by inhibition of autophagy formation in HCT116 human colon cancer cells
    Lee, Yujin
    Sung, Bokyung
    Kang, Yong Jung
    Kim, Dong Hwan
    Jang, Jung-Yoon
    Hwang, Seong Yeon
    Kim, Minjung
    Lim, Hyun Sook
    Yoon, Jeong-Hyun
    Chung, Hae Young
    Kim, Nam Deuk
    INTERNATIONAL JOURNAL OF ONCOLOGY, 2014, 44 (05) : 1599 - 1606
  • [29] Curcumin and 3′ 4′ didemethylnobiletin in combination synergistically inhibit cell proliferation and potentiate apoptosis in HCT116 colon cancer cells
    DiMarco-Crook, Christina
    Zheng, Jinkai
    Song, Minyue
    Xiao, Hang
    FASEB JOURNAL, 2014, 28 (01):
  • [30] Inhibitory Effects of Sophocarpine on Human Colon Cancer HCT116 Cells Via the Mitochondria-Mediated Apoptosis
    Wang, Rui
    Li, Junying
    Li, Li
    LATIN AMERICAN JOURNAL OF PHARMACY, 2019, 38 (05): : 1014 - 1019
12345