Cp*Co(III)-Catalyzed Regioselective Synthesis of Cyclopenta[b]carbazoles via Dual C(sp2)-H Functionalization of 1-(Pyridin-2-yl)-indoles with Diynes

被引：25
|
作者：
Li, Qiuyun [1 ]
Wang, Yanwei [1 ]
Li, Bin [1 ]
Wang, Baiquan [1 ,2 ,3 ]
机构：
[1] Nankai Univ, Coll Chem, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China
[2] Nankai Univ, Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300071, Peoples R China
[3] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
来源：
ORGANIC LETTERS | 2018年 / 20卷 / 24期
基金：
中国国家自然科学基金;
关键词：
C-H ACTIVATION; OXIDATIVE ANNULATION; COUPLING REACTIONS; INTERNAL ALKYNES; INDOLE SYNTHESIS; CYCLIZATION; ACCESS; ARENES; CARBOCYCLIZATION; INTERMEDIATE;
D O I：
10.1021/acs.orglett.8b03438
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Cp*Co(III)-catalyzed synthesis of cyclopenta [b-carbazoles from 1-(pyridin-2-yl)-indoles and diynes is developed. This reaction involves dual C-H activation of indoles and domino cyclizations with diynes and has excellent regioselectivity, high efficiency, a broad substrate scope, and tolerance for various functional groups. A series of cyclopenta[b]carbazole molecular scaffolds are obtained in good to excellent yields.
引用
收藏
页码：7884 / 7887
页数：4
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