Genetic case-control association studies in neuropsychiatry

被引：84
|
作者：
Sullivan, PF [1 ]
Eaves, LJ [1 ]
Kendler, KS [1 ]
Neale, MC [1 ]
机构：
[1] Virginia Commonwealth Univ, Virginia Inst Psychiat & Behav Genet, Richmond, VA 23298 USA
来源：
ARCHIVES OF GENERAL PSYCHIATRY | 2001年 / 58卷 / 11期
关键词：
D O I：
10.1001/archpsyc.58.11.1015
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
Case-control association studies use genetic markers as putative etiologic risk factors. The approach is controversial and has tended to produce associations in neuropsychiatry that do not stand the test of time. We studied the processes that can bias the outcomes away from a true representation of the relationship between a genetic marker and a neuropsychiatric disorder. If conducted with care and mindfulness of the potential pitfalls, case-control association studies can be an important tool for psychiatric genetic research.
引用
收藏
页码：1015 / 1024
页数：10
相关论文
共 50 条
  • [41] A Gaussian copula approach for the analysis of secondary phenotypes in case-control genetic association studies
    He, Jing
    Li, Hongzhe
    Edmondson, Andrew C.
    Rader, Daniel J.
    Li, Mingyao
    BIOSTATISTICS, 2012, 13 (03) : 497 - 508
  • [42] A pseudolikelihood approach for assessing genetic association in case-control studies with unmeasured population structure
    Chen, Yong
    Liang, Kung-Yee
    Tong, Pan
    Beaty, Terri H.
    Barnes, Kathleen C.
    Kao, W. H. Linda
    STATISTICAL METHODS IN MEDICAL RESEARCH, 2020, 29 (11) : 3153 - 3165
  • [43] Omnibus permutation tests of the association of an ensemble of genetic markers with disease in case-control studies
    Potter, DM
    GENETIC EPIDEMIOLOGY, 2006, 30 (05) : 438 - 446
  • [44] Bayesian modeling for genetic association in case-control studies: accounting for unknown population substructure
    Zhang, Li
    Mukherjee, Bhramar
    Ghosh, Malay
    Wu, Rongling
    STATISTICAL MODELLING, 2006, 6 (04) : 352 - 372
  • [45] Robust Tests for Single-marker Analysis in Case-Control Genetic Association Studies
    Li, Qizhai
    Zheng, Gang
    Liang, Xueying
    Yu, Kai
    ANNALS OF HUMAN GENETICS, 2009, 73 : 245 - 252
  • [46] Improving Power for Testing Genetic Association in Case-Control Studies by Reducing the Alternative Space
    Joo, Jungnam
    Kwak, Minjung
    Zheng, Gang
    BIOMETRICS, 2010, 66 (01) : 266 - 276
  • [47] On Testing for Genetic Association in Case-Control Studies When Population Allele Frequencies Are Known
    Antonyuk, A.
    Holmes, C.
    GENETIC EPIDEMIOLOGY, 2009, 33 (05) : 371 - 378
  • [48] Robust trend tests for genetic association in case-control studies using family data
    Tian, X
    Joo, J
    Zheng, G
    Lin, JP
    BMC GENETICS, 2005, 6 (Suppl 1)
  • [49] The Effect of Survival Bias on Case-Control Genetic Association Studies of Highly Lethal Diseases
    Anderson, Christopher D.
    Nalls, Michael A.
    Biffi, Alessandro
    Rost, Natalia S.
    Greenberg, Steven M.
    Singleton, Andrew B.
    Meschia, James F.
    Rosand, Jonathan
    CIRCULATION-CARDIOVASCULAR GENETICS, 2011, 4 (02) : 188 - U265
  • [50] Genetic model selection in two-phase analysis for case-control association studies
    Zheng, Gang
    Ng, Hon Keung Tony
    BIOSTATISTICS, 2008, 9 (03) : 391 - 399
12345