Genetic case-control association studies in neuropsychiatry

被引：84
|
作者：
Sullivan, PF [1 ]
Eaves, LJ [1 ]
Kendler, KS [1 ]
Neale, MC [1 ]
机构：
[1] Virginia Commonwealth Univ, Virginia Inst Psychiat & Behav Genet, Richmond, VA 23298 USA
来源：
ARCHIVES OF GENERAL PSYCHIATRY | 2001年 / 58卷 / 11期
关键词：
D O I：
10.1001/archpsyc.58.11.1015
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
Case-control association studies use genetic markers as putative etiologic risk factors. The approach is controversial and has tended to produce associations in neuropsychiatry that do not stand the test of time. We studied the processes that can bias the outcomes away from a true representation of the relationship between a genetic marker and a neuropsychiatric disorder. If conducted with care and mindfulness of the potential pitfalls, case-control association studies can be an important tool for psychiatric genetic research.
引用
收藏
页码：1015 / 1024
页数：10
相关论文
共 50 条
  • [31] Combining association tests across multiple genetic markers in case-control studies
    Zhou, Huanyu
    Wei, Lee-Jen
    Xu, Xiping
    Xu, Xin
    HUMAN HEREDITY, 2008, 65 (03) : 166 - 174
  • [32] Performance Of Different Balancing Score Methods In Case-Control Genetic Association Studies
    Barhdadi, Amina
    Dube, Marie-Pierre
    GENETIC EPIDEMIOLOGY, 2012, 36 (02) : 168 - 168
  • [33] Bayes Factor Based on a Maximum Statistic for Case-Control Genetic Association Studies
    Wang, Linglu
    Li, Qizhai
    Li, Zhaohai
    Zheng, Gang
    JOURNAL OF AGRICULTURAL BIOLOGICAL AND ENVIRONMENTAL STATISTICS, 2012, 17 (04) : 568 - 582
  • [34] Detecting genetic association in case-control studies using similarity-based association tests
    Zhang, SL
    Kidd, KK
    Zhao, HY
    STATISTICA SINICA, 2002, 12 (01) : 337 - 359
  • [35] The future of genetic case-control studies.
    Schork, NJ
    Fallin, D
    Xu, X
    Blumenfeld, M
    Cohen, D
    AMERICAN JOURNAL OF HUMAN GENETICS, 1999, 65 (04) : A86 - A86
  • [36] Structured Association tests in case-control studies
    Köhler, K
    Bickeböller, H
    ANNALS OF HUMAN GENETICS, 2005, 69 : 768 - 768
  • [37] Phase uncertainty in case-control association studies
    Won, S. W.
    Elston, R. C.
    GENETIC EPIDEMIOLOGY, 2008, 32 (07) : 720 - 720
  • [38] Complexity and power in case-control association studies
    Longmate, JA
    AMERICAN JOURNAL OF HUMAN GENETICS, 2001, 68 (05) : 1229 - 1237
  • [39] Phase Uncertainty in Case-Control Association Studies
    Won, Sungho
    Kim, Sulgi
    Elston, Robert C.
    GENETIC EPIDEMIOLOGY, 2009, 33 (06) : 463 - 478
  • [40] Robust trend tests for genetic association in case-control studies using family data
    Xin Tian
    Jungnam Joo
    Gang Zheng
    Jing-Ping Lin
    BMC Genetics, 6
12345