Prolinol tert-butyldiphenyisilyl ether as organocatalyst for the asymmetric Michael addition of cyclohexanone to nitroolefins

被引：27
|
作者：
Liu, Fengying [1 ]
Wang, Shiwen [1 ]
Wang, Ning [1 ]
Peng, Yungui [1 ]
机构：
[1] SW Univ, Sch Chem & Chem Engn, Chongqing 400715, Peoples R China
来源：
SYNLETT | 2007年 / 15期
关键词：
asymmetric; organocatalyst; Michael addition; cyclohexanone; nitroolefin;
D O I：
10.1055/s-2007-985581
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The direct Michael additions of cyclohexanone to nitroolefins catalyzed by prolinol tert-butyldiphenylsilyl ether were conducted successfully in good yields (up to 99%) and high stereo-selectivities (up to 98:2 diastereomeric ratio and 95% enantiomeric excess).
引用
收藏
页码：2415 / 2419
页数：5
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