Area IV Knockout Reveals How Pdx1 Is Regulated in Postnatal β-Cell Development

被引:6
|
作者
Cox, Aaron R. [1 ]
Kushner, Jake A. [1 ]
机构
[1] Texas Childrens Hosp, Baylor Coll Med, McNair Med Inst, Houston, TX 77030 USA
基金
美国国家卫生研究院;
关键词
NUCLEAR FACTOR 3-BETA; TRANSCRIPTION FACTOR; GENE; EXPRESSION; PANCREAS; REGION; MICE; MATURATION;
D O I
10.2337/dbi17-0036
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:2738 / 2740
页数:3
相关论文
共 50 条
  • [21] Unlocking β-cell restoration: The crucial role of PDX1 in diabetes therapy
    Siwan, Deepali
    Nandave, Mukesh
    Gilhotra, Ritu
    Almalki, Waleed Hassan
    Gupta, Gaurav
    Gautam, Rupesh K.
    PATHOLOGY RESEARCH AND PRACTICE, 2024, 254
  • [22] PDX1, Neurogenin-3, and MAFA: critical transcription regulators for beta cell development and regeneration
    Zhu, Yaxi
    Liu, Qian
    Zhou, Zhiguang
    Ikeda, Yasuhiro
    STEM CELL RESEARCH & THERAPY, 2017, 8
  • [23] Oligonucleotide microarray analysis reveals PDX1 as an essential regulator of mitochondrial metabolism in rat islets
    Gauthier, BR
    Brun, T
    Sarret, EJ
    Ishihara, H
    Schaad, O
    Descombes, P
    Wollheim, CB
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (30) : 31121 - 31130
  • [24] Molecular mechanism in β-cell development: the role of Pdx1, Ngn3 and Pax4 proteins
    Korolija, Marina
    Hadzija, Marijana Popovic
    Hadzija, Mirko
    PERIODICUM BIOLOGORUM, 2009, 111 (01) : 59 - 63
  • [25] Defining the Nkx6.1 Interactome in Beta Cells Reveals a Novel Interaction with Pdx1
    Littlefield, Connor C.
    Jensen, Nathanael C.
    Hill, Jonathon T.
    Price, John C.
    Tessem, Jeffery S.
    DIABETES, 2021, 70
  • [26] CFTR represses a PDX1 axis to govern pancreatic ductal cell fate
    Rotti, Pavana G.
    Yi, Yaling
    Gasser, Grace
    Yuan, Feng
    Sun, Xingshen
    Apak-Evans, Idil
    Wu, Peipei
    Liu, Guangming
    Choi, Soon
    Reeves, Rosie
    Scioneaux, Attilina E.
    Zhang, Yulong
    Winter, Michael
    Liang, Bo
    Cunicelli, Nathan
    Uc, Aliye
    Norris, Andrew W.
    Sussel, Lori
    L., Kristen
    Engelhardt, John F.
    ISCIENCE, 2024, 27 (12)
  • [27] A PDX1 cistrome and single-cell transcriptome resource of the developing pancreas
    Yang, Xiaodun
    Raum, Jeffrey C.
    Kim, Junil
    Yu, Reynold
    Yang, Juxiang
    Rice, Gabriella
    Li, Changhong
    Won, Kyoung-Jae
    Stanescu, Diana E.
    Stoffers, Doris A.
    DEVELOPMENT, 2022, 149 (13):
  • [28] Upregulated Pdx1 and MafA Contribute to β-Cell Function Improvement by Sleeve Gastrectomy
    Feng Li
    Han Cao
    Chunjun Sheng
    Hang Sun
    Kexiu Song
    Shen Qu
    Obesity Surgery, 2016, 26 : 904 - 909
  • [29] Upregulated Pdx1 and MafA Contribute to β-Cell Function Improvement by Sleeve Gastrectomy
    Li, Feng
    Cao, Han
    Sheng, Chunjun
    Sun, Hang
    Song, Kexiu
    Qu, Shen
    OBESITY SURGERY, 2016, 26 (04) : 904 - 909
  • [30] Pdx1 Modulates Pancreatic Beta Cell Survival Via Nix Expression
    Fujimoto, Kei
    Hanson, Piia T.
    Ford, Eric L.
    Tran, Hung
    Dorn, Gerald W., II
    Wice, Burton M.
    Polonsky, Kenneth S.
    DIABETES, 2009, 58 : A404 - A404