Symptomatic Radiation Pneumonitis After Accelerated Partial Breast Irradiation Using Three-dimensional Conformal Radiotherapy

被引：0

作者：

Shikama, Naoto ^{[1
]}

Kumazaki, Yu ^{[1
]}

Miyazawa, Kazunari ^{[1
]}

Miyaura, Kazunori ^{[1
]}

Kato, Shingo ^{[1
]}

Nakamura, Naoki ^{[4
]}

Kawamori, Jiro ^{[5
]}

Shimizuguchi, Takuya ^{[6
]}

Saito, Naoko ^{[2
]}

Saeki, Toshiaki ^{[3
]}

机构：

[1] Saitama Med Univ, Int Med Ctr, Dept Radiat Oncol, 1397-1 Yamane, Hidaka City, Saitama 3501298, Japan

[2] Saitama Med Univ, Int Med Ctr, Dept Radiol, 1397-1 Yamane, Hidaka City, Saitama 3501298, Japan

[3] Saitama Med Univ, Int Med Ctr, Dept Breast Oncol Serv, 1397-1 Yamane, Hidaka City, Saitama 3501298, Japan

[4] Natl Canc Ctr East, Dept Radiat Oncol, Chiba, Japan

[5] St Lukes Int Hosp, Dept Radiat Oncol, Tokyo, Japan

[6] Komagome Hosp, Tokyo Metropolitan Canc & Infect Dis Ctr, Div Radiat Oncol, Tokyo, Japan

来源：

ANTICANCER RESEARCH | 2016年 / 36卷 / 05期

关键词：

Partial breast irradiation; breast cancer; adverse event; three-dimensional conformal radiotherapy; symptomatic pneumonitis; RISK;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aim: To examine the relationship between symptomatic radiation pneumonitis and lung dose-volume parameters for patients receiving accelerated partial breast irradiation (APBI) using three dimensional-conformal radiotherapy (3D-CRT). Patients and Methods: The prescribed radiation dose was 30 Gy in 5 fractions over 10 days. Toxicity was graded according to the Common Terminology Criteria for Adverse Events (version 4.0). Results: Fifty-five patients were enrolled from August 2010 to October 2013 and the median follow-up time was 30 months (range=18-46 months). Three patients (5%) developed grade 2 symptomatic radiation pneumonitis after 3D-CRT APBI. Among 16 patients with ILV10Gy (% ipsilateral lung receiving >= 10 Gy) of 10% or higher, three patients (19%) developed symptomatic radiation pneumonitis. This trend was not observed in any of the patients with ILV10Gy less than 10% (p=0.005). Conclusion: High ILV10Gy might be associated with symptomatic radiation pneumonitis after 3D-CRT APBI.

引用

页码：2475 / 2479

页数：5

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