Structure and function of LIM domain proteins are regulated by alternative splicing

被引：0
|
作者：
Zheng, Quan-Hui [1 ]
Zhang, Ai-Hong [2 ]
Zhao, Yong [3 ]
机构：
[1] North China Univ Sci & Technol, Sch Basic Med Sci, Hebei Key Lab Chron Dis, Tangshan Key Lab Preclin & Basic Res Chron Dis, 57 Jianshe South Rd, Tangshan 063000, Peoples R China
[2] Chinese Acad Sci, Dept Intens Care Unit, Beijing, Peoples R China
[3] Chinese Acad Sci, Inst Zool, Beijing, Peoples R China
来源：
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE | 2016年 / 9卷 / 07期
基金：
中国国家自然科学基金;
关键词：
LIM domain protein; alternative splicing; isoforms; BREAST-CANCER CELLS; CAENORHABDITIS-ELEGANS; PROSTATE-CANCER; NERVOUS-SYSTEM; ENIGMA HOMOLOG; GENE; HIC-5; EXPRESSION; LHX3; TRANSCRIPTION;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
LIM domain proteins display various functions including gene regulation, cell fate determination, tumour formation and cytoskeleton organization. A diverse group of LIM domain proteins have been identified, and alternative RNA splicing combined with alternative transcription/translation initiation or termination sites is one of the key molecular mechanisms contributing to the proteome and functional diversity of LIM domain proteins. However, to date, few of the alternative spliced LIM domain proteins has been fully clarified. Further studies on functional significance of the alternative spliced LIM domain proteins and their relevance to the full length isoforms should be done in a cell and tissue specific manner.
引用
收藏
页码：13281 / 13290
页数：10
相关论文
共 50 条
  • [21] Function of alternative splicing
    Stamm, S
    Ben-Ari, S
    Rafalska, I
    Tang, YS
    Zhang, ZY
    Toiber, D
    Thanaraj, TA
    Soreq, H
    GENE, 2005, 344 : 1 - 20
  • [22] Regulated Alternative Splicing During Myogenesis
    Hall, Megan P.
    Nagel, Roland J.
    Ares, Manuel, Jr.
    FASEB JOURNAL, 2008, 22
  • [23] Predicting the Impact of Alternative Splicing on Plant MADS Domain Protein Function
    Severing, Edouard I.
    van Dijk, Aalt D. J.
    Morabito, Giuseppa
    Busscher-Lange, Jacqueline
    Immink, Richard G. H.
    van Ham, Roeland C. H. J.
    PLOS ONE, 2012, 7 (01):
  • [24] Alternative Splicing of the RAGE Cytoplasmic Domain Regulates Cell Signaling and Function
    Jules, Joel
    Maiguel, Dony
    Hudson, Barry I.
    PLOS ONE, 2013, 8 (11):
  • [25] Alternative splicing of mRNA regulated by Musashi is crucial for photoreceptor development and function.
    Sundar, Jesse
    Stoilov, Peter
    Ramamurthy, Visvanathan
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2017, 58 (08)
  • [26] Alternative splicing of ePAB is regulated by exonic splicing enhancers.
    Seli, E.
    Yaba, A.
    Guzeloglu-Kayisli, O.
    Lalioti, M. D.
    REPRODUCTIVE SCIENCES, 2008, 15 (02) : 230A - 230A
  • [27] LIM-domain-only proteins in cancer
    Matthews, Jacqueline M.
    Lester, Krystal
    Joseph, Soumya
    Curtis, David J.
    NATURE REVIEWS CANCER, 2013, 13 (02) : 111 - 122
  • [28] LIM-domain-only proteins in cancer
    Jacqueline M. Matthews
    Krystal Lester
    Soumya Joseph
    David J. Curtis
    Nature Reviews Cancer, 2013, 13 : 111 - 122
  • [29] Mechanosensitivity in the LIM domain family of proteins.
    Winkelman, J. D.
    Anderson, C. A.
    Kovar, D. R.
    Gardel, M. L.
    MOLECULAR BIOLOGY OF THE CELL, 2018, 29 (26)
  • [30] Single-stranded DNA-binding proteins regulate the abundance of LIM domain and LIM domain-binding proteins
    Xu, Zhixiong
    Meng, Xianzhang
    Cai, Ying
    Liang, Hong
    Nagarajan, Lalitha
    Brandt, Stephen J.
    GENES & DEVELOPMENT, 2007, 21 (08) : 942 - 955
12345