Polymorphisms in the P450C17 (17-hydroxylase/17,20-lyase)and P450C19 (aromatase) genes: Assosiation with serum sex steroids concentrations and bone mineral density in postmenopausal women

被引：0
|
作者：
Somner, J
Mclellan, S
Cheung, J
Mak, YT
Frost, ML
Knapp, KM
Wierebicki, AS
Wheeler, M
Fogelman, I
Ralston, SH
Hampson, G
机构：
[1] St Thomas Hosp, Dept Chem Pathol, London, England
[2] Guys Hosp, Osteoporosis Screening Unit, London SE1 9RT, England
[3] Univ Aberdeen, Sch Med, Dept Med & Therapeut, Bone Res Grp, Aberdeen AB9 1FX, Scotland
来源：
JOURNAL OF BONE AND MINERAL RESEARCH | 2003年 / 18卷 / 07期
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页码：1363 / 1363
页数：1
相关论文
共 50 条
  • [21] Comparison of the hamster and human adrenal P450c17 (17α-hydroxylase/17,20-lyase) using site-directed mutagenesis and molecular modeling
    Mathieu, AP
    Auchus, RJ
    LeHoux, JG
    JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2002, 80 (01): : 99 - 107
  • [22] DEVELOPMENTAL EXPRESSION OF GENES FOR THE STEREOIDOGENIC ENZYMES P450SCC (20,22-DESMOLASE), P450C17 (17-ALPHA-HYDROXYLASE 17,20-LYASE), AND P450C21 (21-HYDROXYLASE) IN THE HUMAN-FETUS
    VOUTILAINEN, R
    MILLER, WL
    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1986, 63 (05): : 1145 - 1150
  • [23] A SINGLE GENE ENCODES ADRENAL AND TESTICULAR P450C17 (17-ALPHA-HYDROXYLASE/17,20 LYASE)
    PICADOLEONARD, J
    MILLER, WL
    CLINICAL RESEARCH, 1987, 35 (01): : A206 - A206
  • [24] Differential inhibition of 17α-hydroxylase and 17,20-lyase activities by three novel missense CYP17 mutations identified in patients with P450c17 deficiency
    Van Den Akker, ELT
    Koper, JW
    Boehmer, ALM
    Themmen, APN
    Verhoef-Post, M
    Timmerman, MA
    Otten, BJ
    Drop, SLS
    De Jong, FH
    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2002, 87 (12): : 5714 - 5721
  • [25] EXPRESSION AND PURIFICATION OF FUNCTIONAL HUMAN 17-ALPHA-HYDROXYLASE/17,20-LYASE (P450C17) IN ESCHERICHIA-COLI - USE OF THIS SYSTEM FOR STUDY OF A NOVEL FORM OF COMBINED 17-ALPHA-HYDROXYLASE/17,20-LYASE DEFICIENCY
    IMAI, T
    GLOBERMAN, H
    GERTNER, JM
    KAGAWA, N
    WATERMAN, MR
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1993, 268 (26) : 19681 - 19689
  • [26] In-Vitro Potency and Safety Index of Three Novel P450c17 17,20-Lyase Inhibitors.
    Rafferty, S. W.
    Eisner, J. R.
    Hoekstra, W. J.
    Higgins, A. J.
    Schotzinger, R.
    ENDOCRINE REVIEWS, 2010, 31 (03)
  • [27] Effect of (xeno)-estrogens on zebrafish P450c17 (C17,17 alpha-hydroxylase/17,20-lyase) mRNA and protein expression in gonadal tissue
    Brion, Francois
    Hinfray, Nathalie
    Palluel, Olivier
    Maillard, Julien
    Anglade, Isabelle
    Ait-Aissa, Selim
    Kah, Olivier
    Porcher, Jean-Marc
    CYBIUM, 2008, 32 (02): : 245 - 246
  • [28] Effects of Anticonvulsants on human P450c17 (17α-hydroxylase/17,20 lyase) and 3ß-hydroxysteroid dehydrogenase type 2
    Flück, CE
    Yaworsky, DC
    Miller, WL
    EPILEPSIA, 2005, 46 (03) : 444 - 448
  • [29] Immunohistochemical localization and biological activity of the steroidogenic enzyme cytochrome P450 17α-hydroxylase/C17, 20-lyase (P450C17) in the frog brain and pituitary
    Do Rego, Jean Luc
    Tremblay, Yves
    Luu-The, Van
    Repetto, Emanuela
    Castel, Helene
    Vallarino, Mauro
    Belanger, Alain
    Pelletier, Georges
    Vaudry, Hubert
    JOURNAL OF NEUROCHEMISTRY, 2007, 100 (01) : 251 - 268
  • [30] CLONING AND SEQUENCE OF THE HUMAN-GENE FOR P450C17 (STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE) - SIMILARITY WITH THE GENE FOR P450C21
    PICADOLEONARD, J
    MILLER, WL
    DNA-A JOURNAL OF MOLECULAR & CELLULAR BIOLOGY, 1987, 6 (05): : 439 - 448
12345