Swim Training Attenuates Inflammation and Improves Insulin Sensitivity in Mice Fed with a High-Fat Diet

被引：8
|
作者：
Zhang, Guangzeng [1 ]
Yu, Pengfei [1 ]
Liu, Xiaomeng [1 ]
机构：
[1] Zhoukou Normal Univ, Coll Life Sci & Agron, Inst Neurosci & Translat Med, Zhoukou 466001, Henan, Peoples R China
来源：
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY | 2017年 / 2017卷
基金：
中国国家自然科学基金;
关键词：
NECROSIS-FACTOR-ALPHA; LIFE-STYLE MANAGEMENT; ADIPOSE-TISSUE; HEPATIC STEATOSIS; MACROPHAGE INFILTRATION; ADIPOCYTE DEATH; INDUCED OBESITY; RESISTANCE; ENDOTOXEMIA; EXPRESSION;
D O I：
10.1155/2017/5940732
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Exercise could afford multiple beneficial effects on obesity-related metabolic disorders. To address this issue, C57BL/6J mice were used to investigate the effects of 13 weeks of swim training on HFD-induced obesity and related insulin resistance and inflammation. Our results show that swim training can significantly prevent HFD-induced weight gain and increase resting energy expenditure without affecting food intake. The insulin sensitivity was enhanced in the HFD + swim group than in the HFD + sedentary group. Moreover, swim training considerably decreased serum LPS content and downregulates epididymis white adipose tissue (eWAT) expression of the inflammatory mediator Tnf-alpha, Il-6, and Mcp-1. In summary, 13 weeks of swim training could reverse HFD-induced metabolic disorders including insulin resistance and inflammation.
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页数：6
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