Design, synthesis and cytotoxicity evaluation of novel (E)-3-(3-aryl-1-phenyl-1H-pyrazol-4-yl)-1-(pyridin-3-yl)prop-2-en-1-ones as anticancer agents

被引：8
|
作者：
Alam, Raquib [1 ]
Alam, Md. Aftab [2 ]
Panda, Amulya K. [3 ]
Uddin, Rahis [1 ]
机构：
[1] Jamia Millia Islamia, Dept Chem, New Delhi 110025, India
[2] Galgotias Univ, Dept Pharm, Sch Med & Allied Sci, Greater Noida 201301, UP, India
[3] Natl Inst Immunol, Prod Dev Cell, New Delhi 110067, India
来源：
HETEROCYCLIC COMMUNICATIONS | 2016年 / 22卷 / 04期
关键词：
chalcones; Claisen-Schmidt condensation; cytotoxic activity; pyrazoles; PROSTATE-CANCER CELLS; BIOLOGICAL EVALUATION; CHALCONE DERIVATIVES; DUAL INHIBITORS; IN-VITRO; CELECOXIB; PYRAZOLES; GROWTH; CYCLIZATION; RESISTANCE;
D O I：
10.1515/hc-2016-0042
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
(E)-3-(3-Aryl-1-phenyl-1H-pyrazol-4-yl)-1-(pyridin-3-yl)prop-2-en-1-ones 4a-i have been synthesized and evaluated for their in vitro cytotoxicity against a panel of three human cancer cell lines Caco-2, MIA PaCa-2, MCF-7 and a normal NIH-3T3 cell line. Compound 4g is cytotoxic with the IC50 value of 15.32 +/- 0.62 mu m against the Caco-2 cell line.
引用
收藏
页码：221 / 225
页数：5
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