Design, synthesis and cytotoxicity evaluation of novel (E)-3-(3-aryl-1-phenyl-1H-pyrazol-4-yl)-1-(pyridin-3-yl)prop-2-en-1-ones as anticancer agents

被引：8

作者：

Alam, Raquib ^{[1
]}

Alam, Md. Aftab ^{[2
]}

Panda, Amulya K. ^{[3
]}

Uddin, Rahis ^{[1
]}

机构：

[1] Jamia Millia Islamia, Dept Chem, New Delhi 110025, India

[2] Galgotias Univ, Dept Pharm, Sch Med & Allied Sci, Greater Noida 201301, UP, India

[3] Natl Inst Immunol, Prod Dev Cell, New Delhi 110067, India

来源：

HETEROCYCLIC COMMUNICATIONS | 2016年 / 22卷 / 04期

关键词：

chalcones; Claisen-Schmidt condensation; cytotoxic activity; pyrazoles; PROSTATE-CANCER CELLS; BIOLOGICAL EVALUATION; CHALCONE DERIVATIVES; DUAL INHIBITORS; IN-VITRO; CELECOXIB; PYRAZOLES; GROWTH; CYCLIZATION; RESISTANCE;

D O I：

10.1515/hc-2016-0042

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

(E)-3-(3-Aryl-1-phenyl-1H-pyrazol-4-yl)-1-(pyridin-3-yl)prop-2-en-1-ones 4a-i have been synthesized and evaluated for their in vitro cytotoxicity against a panel of three human cancer cell lines Caco-2, MIA PaCa-2, MCF-7 and a normal NIH-3T3 cell line. Compound 4g is cytotoxic with the IC50 value of 15.32 +/- 0.62 mu m against the Caco-2 cell line.

引用

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页码：221 / 225

页数：5

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